Abstract
We studied the distribution of two genetic polymorphisms (APOE and APOC1) in a sample of 100 subjects fulfilling the NIMH criteria for age-associated memory impairment (AAMI) and 124 controls. We found significant associations both for APOE and APOC1 loci and their combinations with the AAMI condition. The findings in our sample suggest that memory-impaired subjects as described by the NIMH may be genetically differentiated from normally aging subjects in relation to these two polymorphisms and indicate the interest of considering variations in the APOC1 gene for further studies in cognitive aging.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Bartrés-Faz, .D., Clemente, I., Junqué, .C. et al. APOE and APOC1 genetic polymorphisms in age-associated memory impairment. Neurogenetics 3, 215–219 (2001). https://doi.org/10.1007/s100480100122
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s100480100122