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Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress

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Abstract

Some dialysis patients are treated with post-hemodiafiltration (HDF); the blood viscosity of the patients who undergo post-HDF is higher than that of the patients who undergo conventional hemodialysis. This study aims to evaluate poly(N-vinyl-2-pyrrolidone) (PVP) elution from PSf dialysis membranes by varying solvents and high wall shear stress caused by blood viscosity. We tested three commercial membranes: APS-15SA (Asahi Kasei Kuraray), CX-1.6U (Toray) and FX140 (Fresenius). Dialysate and blood sides of the dialyzers were primed with reverse osmosis (RO) water and saline. RO water, saline and dextran solution (2.9 and 5.8 mPa s) were circulated in the blood side. The amount of eluted PVP was determined by 0.02 N iodometry. The hardness and adsorption force of human serum albumin (HSA) on the membrane surfaces were measured by the atomic force microscope. When wall shear stress was increased using dextran, the amount of PVP eluted by the 2.9 mPa s solution equaled that eluted by the 5.8 mPa s solution with APS-15SA and CX-1.6U sterilized by gamma rays. The amount of PVP eluted by the 5.8 mPa s solution was higher than that eluted by the 2.9 mPa s solution with FX140 sterilized by autoclaving. The wall shear stress increased the PVP elution from the surface, hardness and adsorption force of HSA. Sufficient gamma-ray irradiation is effective in decreasing PVP elution.

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Acknowledgments

This study was carried out as part of the Global COE program "Center for Practical Chemical Wisdom" of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

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Authors and Affiliations

  1. Sakai Laboratory, Department of Chemical Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Koki Namekawa, Masato Matsuda, Ami Kaneko & Kiyotaka Sakai

  2. Department of Medical Engineering, Himeji Dokkyo University, 7-2-1 Kamiono, Himeji, Hyogo, 670-8524, Japan

    Makoto Fukuda

Authors
  1. Koki Namekawa
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  2. Masato Matsuda
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  3. Makoto Fukuda
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  4. Ami Kaneko
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  5. Kiyotaka Sakai
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Correspondence to Koki Namekawa or Kiyotaka Sakai.

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Namekawa, K., Matsuda, M., Fukuda, M. et al. Poly(N-vinyl-2-pyrrolidone) elution from polysulfone dialysis membranes by varying solvent and wall shear stress. J Artif Organs 15, 185–192 (2012). https://doi.org/10.1007/s10047-012-0629-5

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  • DOI: https://doi.org/10.1007/s10047-012-0629-5

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