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Application of wide-field optical coherence tomography to monitoring of viability of rat brain in vivo

  • Special Section: The Tenth Japan-Finland Joint Symposium on Optics in Engineering “OIE’13, Utsunomiya”
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Abstract

We investigated the feasibility of OCT in monitoring the viability of the brain. It was confirmed that after an overdose of pentobarbital sodium salt for an euthanasia, the OCT signal intensity increased before cardiac arrest and finally became 2.7 times, and by periodically changing the tissue temperature from 20 to 32 °C in vivo, average correlation coefficients between the ratio of signal intensity (RSI) and temperature were determined to be −0:42 to −0:50. RSI reversibly changed with subsequent variations of temperatures and finally increased rapidly just before cardiac arrest. These results indicate that RSI could correspond to decreases in viability.

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Authors and Affiliations

  1. Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata, 992-8510, Japan

    Manabu Sato

  2. Tokyo University of Agriculture and Technology, Koganei, Tokyo, 184-8588, Japan

    Izumi Nishidate

Authors
  1. Manabu Sato
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  2. Izumi Nishidate
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Correspondence to Manabu Sato.

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Sato, M., Nishidate, I. Application of wide-field optical coherence tomography to monitoring of viability of rat brain in vivo. OPT REV 21, 333–338 (2014). https://doi.org/10.1007/s10043-014-0050-9

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  • DOI: https://doi.org/10.1007/s10043-014-0050-9

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