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The impact of hydrophobic hernia mesh coating by omega fatty acid on atraumatic fibrin sealant fixation

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An Erratum to this article was published on 20 February 2015

Abstract

Background

Fibrin sealant (FS) is a safe and efficient fixation method in open intraperitoneal hernia repair. While favourable results have been achieved with hydrophilic meshes, hydrophobic (such as Omega fatty acid coated) meshes (OFM) have not been specifically assessed so far. Atrium C-qur lite® mesh was tested in rats in models of open onlay and intraperitoneal hernia repair.

Methods

44 meshes (2 × 2 cm) were implanted in 30 male Sprague–Dawley rats in open (n = 2 meshes per animal) and intraperitoneal technique (IPOM; n = 1 mesh per animal). Animals were randomised to four groups: onlay and IPOM sutured vs. sealed. Follow-up was 6 weeks, sutured groups serving as controls. Evaluation criteria were mesh dislocation, adhesions and foreign body reaction.

Results

FS provided a reliable fixation in onlay technique, whereas OFM meshes dislocated in the IPOM position when sealed only.

Conclusion

FS mesh fixation was safe with OFM meshes in open onlay repair. Intraperitoneal placement of hydrophobic meshes requires additional fixation and cannot be achieved with FS alone.

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References

  1. Anurov MV, Titkova SM, Oettinger AP (2011) Biomechanical compatibility of surgical mesh and fascia being reinforced: dependence of experimental hernia defect repair results on anisotropic surgical mesh positioning. Hernia 12(2):199–210. doi:10.1007/s10029-011-0877-y

    Google Scholar 

  2. Brown CN, Finch JG (2010) Which mesh for hernia repair? Ann R Coll Surg Engl 92:272–278

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Deeken CR, Faucher KM, Matthews BD (2012) A review of the composition, characteristics, and effectiveness of barrier mesh prostheses utilized for laparoscopic ventral hernia repair. Surg Endosc 26:566–575

    Article  PubMed  Google Scholar 

  4. Deerenberg EB, Mulder IM, Grotenhuis N, Ditzel M, Jeekel J, Lange JF (2012) Experimental study on synthetic and biological mesh implantation in a contaminated environment. Br J Surg 99:1734–1741

    Article  CAS  PubMed  Google Scholar 

  5. Eliason BJ, Frisella MM, Matthews BD, Deeken CR (2011) Effect of repetitive loading on the mechanical properties of synthetic hernia repair materials. J Am Coll Surg 213:430–435

    Article  PubMed  Google Scholar 

  6. Engelsman AF, van der Mei HC, Busscher HJ, Ploeg RJ (2008) Morphological aspects of surgical meshes as a risk factor for bacterial colonization. Br J Surg 95:1051–1059

    Article  CAS  PubMed  Google Scholar 

  7. Eriksen JR, Bisgaard T, Assaadzadeh S, Nannestad JL, Rosenberg J (2011) Randomized clinical trial of fibrin sealant versus titanium tacks for mesh fixation in laparoscopic umbilical hernia repair. Br J Surg 98:1537–1545

    Article  CAS  PubMed  Google Scholar 

  8. Fortelny RH, Petter-Puchner AH, Ferguson J, Gruber-Blum S, Brand J, Mika K, Redl H (2011) A comparative biomechanical evaluation of hernia mesh fixation by fibrin sealant. J Surg Res 171:576–581

    Article  PubMed  Google Scholar 

  9. Fortelny RH, Petter-Puchner AH, Glaser KS, Redl H (2012) Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review. Surg Endosc 26:1803–1812

    Article  PubMed  Google Scholar 

  10. Fortelny RH, Schwab R, Glaser KS, Puchner KU, May C, Konig F, Redl H, Petter-Puchner AH (2008) The assessment of quality of life in a trial on lightweight mesh fixation with fibrin sealant in transabdominal preperitoneal hernia repair. Hernia 12:499–505

    Article  CAS  PubMed  Google Scholar 

  11. Gruber-Blum S, Petter-Puchner AH, Brand J, Fortelny RH, Walder N, Oehlinger W, Koenig F, Redl H (2011) Comparison of three separate antiadhesive barriers for intraperitoneal onlay mesh hernia repair in an experimental model. Br J Surg 98:442–449

    Article  CAS  PubMed  Google Scholar 

  12. Gruber-Blum S, Petter-Puchner AH, Mika K, Brand J, Redl H, Ohlinger W, Benesch T, Fortelny RH (2010) A comparison of a bovine albumin/glutaraldehyde glue versus fibrin sealant for hernia mesh fixation in experimental onlay and IPOM repair in rats. Surg Endosc 24:3086–3094

    Article  CAS  PubMed  Google Scholar 

  13. Jenkins ED, Melman L, Frisella MM, Deeken CR, Matthews BD (2010) Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant. Hernia 14:505–509

    Article  CAS  PubMed  Google Scholar 

  14. Johansson M, Gunnarsson U, Strigard K (2011) Different techniques for mesh application give the same abdominal muscle strength. Hernia 15:65–68

    Article  CAS  PubMed  Google Scholar 

  15. Kingsnorth AN, Shahid MK, Valliattu AJ, Hadden RA, Porter CS (2008) Open onlay mesh repair for major abdominal wall hernias with selective use of components separation and fibrin sealant. World J Surg 32:26–30

    Article  PubMed  Google Scholar 

  16. Oh SH, Kang SG, Kim ES, Cho SH, Lee JH (2003) Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. Biomaterials 24:4011–4021

    Article  CAS  PubMed  Google Scholar 

  17. Olmi S, Cesana G, Sagutti L, Pagano C, Vittoria G, Croce E (2010) Laparoscopic incisional hernia repair with fibrin glue in select patients. JSLS 14:240–245

    Article  PubMed  Google Scholar 

  18. Olmi S, Scaini A, Erba L, Croce E (2007) Use of fibrin glue (Tissucol((R))) in laparoscopic repair of abdominal wall defects: preliminary experience. Surg Endosc 21:409–413

    Article  CAS  PubMed  Google Scholar 

  19. Petter-Puchner A, Fortelny R, Mittermayr R, Öhinger W, Redl H (2005) Fibrin sealing vs. stapling of hernia meshes in an onlay model in the rat. Hernia 9:322–329

    Article  PubMed  Google Scholar 

  20. Petter-Puchner AH, Fortelny RH, Mittermayr R, Walder N, Ohlinger W, Redl H (2006) Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc 20:942–946

    Article  CAS  PubMed  Google Scholar 

  21. Petter-Puchner AH, Walder N, Redl H, Schwab R, Ohlinger W, Gruber-Blum S, Fortelny RH (2008) Fibrin sealant (tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intraabdominal peritoneal onlay mesh repair. J Surg Res 150:190–195

    Article  CAS  PubMed  Google Scholar 

  22. Raptis DA, Vichova B, Breza J, Skipworth J, Barker S (2011) A comparison of woven versus nonwoven polypropylene (PP) and expanded versus condensed polytetrafluoroethylene (PTFE) on their intraperitoneal incorporation and adhesion formation. J Surg Res 169:1–6

    Article  CAS  PubMed  Google Scholar 

  23. Rentsch B, Hofmann A, Breier A, Rentsch C, Scharnweber D (2009) Embroidered and surface modified polycaprolactone-co-lactide scaffolds as bone substitute: in vitro characterization. Ann Biomed Eng 37:2118–2128

    Article  PubMed  Google Scholar 

  24. Rieder E, Stoiber M, Scheikl V, Poglitsch M, Dal BA, Prager G, Schima H (2011) Mesh fixation in laparoscopic incisional hernia repair: glue fixation provides attachment strength similar to absorbable tacks but differs substantially in different meshes. J Am Coll Surg 212:80–86

    Article  PubMed  Google Scholar 

  25. Schopf S, von AT, von AM, Schardey H (2011) Chronic pain after laparoscopic transabdominal preperitoneal hernia repair: a randomized comparison of light and extralight titanized polypropylene mesh. World J Surg 35:302–310

    Article  PubMed Central  PubMed  Google Scholar 

  26. Schreinemacher MH, Emans PJ, Gijbels MJ, Greve JW, Beets GL, Bouvy ND (2009) Degradation of mesh coatings and intraperitoneal adhesion formation in an experimental model. Br J Surg 96:305–313

    Article  CAS  PubMed  Google Scholar 

  27. Schug-Pass C, Lippert H, Kockerling F (2009) Fixation of mesh to the peritoneum using a fibrin glue: investigations with a biomechanical model and an experimental laparoscopic porcine model. Surg Endosc 23:2809–2815

    Article  CAS  PubMed  Google Scholar 

  28. Schwab R, Schumacher O, Junge K, Binnebosel M, Klinge U, Becker HP, Schumpelick V (2008) Biomechanical analyses of mesh fixation in TAPP and TEP hernia repair. Surg Endosc 22:731–738

    Article  CAS  PubMed  Google Scholar 

  29. Voskerician G, Rodriguez A, Gingras PH (2007) Macroporous condensed poly(tetra fluoro-ethylene). II. In vivo effect on adhesion formation and tissue integration. J Biomed Mater Res A 82:426–435

    Article  PubMed  Google Scholar 

  30. Wauschkuhn CA, Schwarz J, Boekeler U, Bittner R (2010) Laparoscopic inguinal hernia repair: gold standard in bilateral hernia repair? Results of more than 2800 patients in comparison to literature. Surg Endosc 24:3026–3030

    Article  PubMed  Google Scholar 

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Conflict of interest

SGB, JB, CK, RF and APP declare no conflict of interest. HR declares conflict of interest not directly related to this study, working as a senior consultant for Baxter Biosciences.

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Authors and Affiliations

  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200, Vienna, Austria

    S. Gruber-Blum, C. Keibl, H. Redl & A. H. Petter-Puchner

  2. Department of Traumatology, Federal Hospital Horn, Spitalgasse 10, 3580, Horn, Austria

    J. Brand

  3. Department of General, Visceral and Oncological Surgery, Wilhelminenspital, Montleartstrasse 37, 1171, Vienna, Austria

    R. H. Fortelny, C. May & A. H. Petter-Puchner

  4. Paracelsus Medizinische Privatuniversität, Strubergasse 21, 5020, Salzburg, Austria

    R. H. Fortelny

Authors
  1. S. Gruber-Blum
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  2. J. Brand
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  3. C. Keibl
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  4. H. Redl
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  5. R. H. Fortelny
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  6. C. May
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  7. A. H. Petter-Puchner
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Corresponding author

Correspondence to A. H. Petter-Puchner.

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Gruber-Blum, S., Brand, J., Keibl, C. et al. The impact of hydrophobic hernia mesh coating by omega fatty acid on atraumatic fibrin sealant fixation. Hernia 19, 651–657 (2015). https://doi.org/10.1007/s10029-014-1304-y

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  • DOI: https://doi.org/10.1007/s10029-014-1304-y

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