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Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012

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Abstract

With the goal of discussing how the neuropathology community should resolve the controversy over the diagnosis of oligodendroglioma, this Satellite Workshop reflects the collaboration between two invited keynote speakers: Dr. Johan M. Kros of the Erasmus Medical Center and Dr. Kenneth D. Aldape of the University of Texas MD Anderson Cancer Center and the Organizing Committee of the Japanese Society of Brain Tumor Pathology. In the first half of the workshop, the keynote speakers reviewed the current status of the pathology and genetics of oligodendroglioma. In the second half, six debatable cases that exemplify the current controversies over the diagnosis of oligodendroglioma were presented. The consensus diagnoses in these six cases, which have been reviewed by members of the Society, were opened to discussion and comments by the speakers. These cases highlight unresolved issues in the WHO 2007 classification of oligodendrogliomas, particularly the discordance between morphology and genetics. To achieve synchronization between phenotypes and genotypes, the neuropathology diagnosis should focus on the classic features of oligodendrogliomas that are highly correlated with the genetic background.

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Acknowledgments

The authors deeply thank Dr. Takashi Maruyama and Dr. Yoshikazu Okada, Department of Neurosurgery and Dr. Yoshihiro Muragaki, Faculty of Advanced Techno-Surgery, Institute of Advanced, Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women’s Medical University for their support for the project and generous permission to use the clinical information as well as images for the workshop. The authors also thank Dr. Nobutaka Arai and the stuff of Brain Pathology Research Center of Tokyo Metropolitan Institute of Medical Science for archiving virtual slide-images of the specimens to database.

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this report or the findings specified in this paper.

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Author notes

  1. Takanori Hirose

    Present address: Pathology for Regional Communication, Kobe University, Kobe, Japan

  2. Makoto Shibuya

    Present address: Central Laboratory, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan

    Takashi Komori

  2. Department of Pathology, Graduate School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan

    Takashi Komori

  3. Brain Pathology Research Center, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Takashi Komori

  4. Department of Pathology, Tokushima Prefectural Central Hospital, Tokushima, Japan

    Takanori Hirose

  5. Department of Pathology, Ibaragi Medical Center, Tokyo Medical University, Tokyo, Japan

    Makoto Shibuya

  6. Department of Laboratory Medicine and Pathology, Sendai Medical Center, Sendai, Japan

    Hiroyoshi Suzuki

  7. Department of Cancer Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Shinya Tanaka

  8. Department of Pathology, Saitama Medical University, Saitama, Japan

    Atsushi Sasaki

Authors
  1. Takashi Komori
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  2. Takanori Hirose
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  3. Makoto Shibuya
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  4. Hiroyoshi Suzuki
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  5. Shinya Tanaka
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  6. Atsushi Sasaki
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Corresponding author

Correspondence to Takashi Komori.

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Komori, T., Hirose, T., Shibuya, M. et al. Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012. Brain Tumor Pathol 30, 253–261 (2013). https://doi.org/10.1007/s10014-013-0165-x

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  • DOI: https://doi.org/10.1007/s10014-013-0165-x

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