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Glioblastomas: correlation between oligodendroglial components, genetic abnormalities, and prognosis

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Abstract

It has been demonstrated that a small percentage (approximately 15%) of glioblastomas (GBM) presents an oligodendroglial component with a variable frequency of chromosome 1p and 19q deletions, the genetic alteration related to chemotherapy response and longer survival in oligodendrogliomas. There is a growing interest in investigating 1p and 19q losses in hybrid gliomas and their impact on prognosis. A series of 88 GBMs was investigated regarding 1p and/or 19q losses, 24 with oligodendroglioma-like areas, using quantitative microsatellite analysis and/or fluorescent in situ hybridization. When present, the oligodendroglial and astrocytic components were independently investigated. Clinical data, histology, and 1p/19q status were correlated. Tumors with oligodendroglial components showed three cases each of 1p or 19q loss and one with combined 1p/19q loss. No difference in 1p or 19q status was observed between the oligodendroglial and astrocytic components. Conventional GBM demonstrated isolated 1p loss in four cases and 19q loss in five. No association was seen between 1p/19q status and histology. Deletions at 1p and/or 19q were infrequent in GBMs with oligodendroglial components. Despite the hybrid phenotype, the pattern of genetic changes at 1p and 19q was not different from that usually observed in conventional GBMs, nor did it show any correlation with survival.

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Acknowledgments

The authors thank Carlos Ferreira Nascimento, Jose Ivanildo Neves, and Fabricio de Carvalho for their technical assistance and Judy Grevan for editing the text. This project was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), grant ID 04/12360-2.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Hospital A C Camargo, São Paulo, SP, Brazil

    Luciana Wernersbach Pinto, Maria Betania Mahler Araújo & Fernando Augusto Soares

  2. Ludwig Institute for Cancer Research, São Paulo, SP, Brazil

    Andre L. Vettore

  3. Instituto Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil

    Liana Wernersbach

  4. Department of Radiotherapy, Hospital A C Camargo, São Paulo, SP, Brazil

    André Campana C. Leite

  5. Department of Pathology, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    Leila Maria C. Chimelli

  6. Laboratorio de Patologia, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, 21040-900, Rio de Janeiro, RJ, Brasil

    Luciana Wernersbach Pinto

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  1. Luciana Wernersbach Pinto
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  2. Maria Betania Mahler Araújo
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Correspondence to Luciana Wernersbach Pinto.

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Pinto, L.W., Mahler Araújo, M.B., Vettore, A.L. et al. Glioblastomas: correlation between oligodendroglial components, genetic abnormalities, and prognosis. Virchows Arch 452, 481–490 (2008). https://doi.org/10.1007/s00428-007-0562-9

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  • DOI: https://doi.org/10.1007/s00428-007-0562-9

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