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A selective determination of norepinephrine on the glassy carbon electrode modified with poly(ethylenedioxypyrrole dicarboxylic acid) nanofibers

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Abstract

A glassy carbon electrode modified with poly(3,4-ethylenedioxypyrrole-2,5-dicarboxylic acid) nanofibers (PEDOPA-NFs) was prepared for the determination of norepinephrine (NE) in phosphate buffer saline. The modified electrode demonstrated an improved sensitivity and selectivity toward the electrochemical detection of NE and could detect separately ascorbic acid (AA), uric acid (UA), and NE in their mixture. The separations of the oxidation peak potentials of NE–AA and NE–UA were 160 and 150 mV, respectively. Meanwhile, the modified electrode showed higher sensitivity and selectivity toward NE than dopamine and epinephrine. Using differential pulse voltammetry, the oxidation peak current of NE was found to be linearly dependent on its concentration within the range of 0.3–10 μM, and the detection limit of the NE oxidation current was 0.05 μM at a signal-to-noise ratio of 3. The PEDOPA-NFs promoted the electron transfer reaction of NE, while the PEDOPA-NFs, acting as a negatively charged linker, combined with the positively charged NE to induce NE accumulation in the NFs at pH under 7.4. However, the PEDOPA-NFs restrained the electrochemical response of the negatively charged AA and UA due to the electrostatic repulsion. The result indicates that the modified electrode can be used to determine NE without interference from AA and UA and selectively in the mixture of catecholamines.

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Acknowledgments

This work was supported by a Research Foundation Grant funded by Chonnam National University (2008).

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Authors and Affiliations

  1. Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju, 500-757, Korea

    Heejin Seol & Seungwon Jeon

  2. Momed Co., Oryong-dong Buk-gu, Gwangju, 500-480, Korea

    Haesang Jeong

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  1. Heejin Seol
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  2. Haesang Jeong
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Correspondence to Seungwon Jeon.

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Seol, H., Jeong, H. & Jeon, S. A selective determination of norepinephrine on the glassy carbon electrode modified with poly(ethylenedioxypyrrole dicarboxylic acid) nanofibers. J Solid State Electrochem 13, 1881–1887 (2009). https://doi.org/10.1007/s10008-008-0766-1

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