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Radiation-induced olfactory neuroblastoma: a new etiology is possible

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Abstract

Purpose

Radiation-induced olfactory neuroblastoma (ONB) is an uncommon neoplasm that is generally associated with a poor prognosis. We describe a new case of olfactory neuroblastoma in a patient previously treated for astrocytoma with holocranial radiotherapy 9 years ago.

Materials and methods

We reviewed the medical records of four patients with radiation-induced olfactory neuroblastoma between 2001 and 2009.

Results

This work supports the idea that ONB can be induced by radiation.

Conclusions

As radiotherapy is a standard treatment in other tumors, clinicians must be aware of the possibility of a second tumor induced by radiation.

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Acknowledgements

The authors are grateful to Francisco Fayos Ferrer from the Medical Physics and Radiation Protection Service, Ruber International Hospital, Madrid, for his assistance with the figures and are grateful to Thomas O'Boyle for his help with the final English version.

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Authors and Affiliations

  1. Oral and Maxillofacial Surgery Service, Gregorio Maranon Hospital, Complutense University, Madrid, Spain

    Veronica Perez Garcia

  2. Pathology Service, Gregorio Maranon Hospital, Complutense University, Madrid, Spain

    Maria de los Angeles Martinez Izquierdo

Authors
  1. Veronica Perez Garcia
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  2. Maria de los Angeles Martinez Izquierdo
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Corresponding author

Correspondence to Maria de los Angeles Martinez Izquierdo.

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Perez Garcia, V., Martinez Izquierdo, M. Radiation-induced olfactory neuroblastoma: a new etiology is possible. Oral Maxillofac Surg 15, 71–77 (2011). https://doi.org/10.1007/s10006-010-0234-9

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  • DOI: https://doi.org/10.1007/s10006-010-0234-9

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