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Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6)

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Abstract

Although the understanding of the complex pathogenesis for osteoporosis is appreciable, the underlying mechanism is not yet fully elucidated. There is a great need to further characterize the available animal models in osteoporosis research. The senescence-accelerated mouse prone 6 (SAMP6) mice have been developed as the spontaneous experimental model for senile osteoporosis. Here, we provide a comprehensive overview of current research regarding the bone morphological and molecular alterations and the possible mechanisms involved in these changes. There were significant decrease in trabecular bone mass at the axial and appendicular skeletal sites, with no marked alterations of cortical bone. Decreased bone formation on the endosteal surface and trabecular bone, and increased bone marrow adiposity were observed in SAMP6 mice. The elevated expression level of proliferator activator gamma (PPARγ) in the bone marrow suggest that PPARγ might regulate osteoblastic bone formation negatively in SAMP6 mice. The expression level of secreted frizzled-related protein 4 (Sfrp4) was found to be higher in SAMP6 mice. Sfrp4 is considered to suppress osteoblastic proliferation mediated by inhibition of Wnt signaling pathway. These findings may help us to gain more insight into the potential mechanism of senile osteoporosis.

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Fig. 1

(modified from Ref. [21]). As compared with SAMR1, trabecular bone decreased and medullary cavity enlarged in SAMP6 mice. a, c, e SAMR1 mice; b, d, f SAMP6 mice. Scale bar 0.5 mm

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Authors and Affiliations

  1. Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

    Kagaku Azuma & Qian Zhou

  2. Department of Food Science and Nutrition, Faculty of Human Life and Environmental Science, Nagoya Women’s University, 3-40 Shioji-cho, Mizuho-ku, Nagoya, Aichi, 467-8610, Japan

    Kin-ya Kubo

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  1. Kagaku Azuma
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Correspondence to Kagaku Azuma.

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Azuma, K., Zhou, Q. & Kubo, Ky. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6). Med Mol Morphol 51, 139–146 (2018). https://doi.org/10.1007/s00795-018-0188-9

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