Abstract
We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectron microscopic techniques. Immunohistochemically, myofibroblasts, which were positive for alpha-smooth muscle actin (ASMA) and negative for high molecular weight caldesmon (h-CD), were observed in the stroma just beneath the epithelium of normal seminal vesicles. Moreover, an electron microscope examination revealed the presence of spindle or stellate cells in the stroma of the lamina propria beneath the seminal vesicle epithelium, and an immunoelectron microscopic examination showed that these cells were positive for ASMA. Finally, myofibroblasts are distributed in the lamina propria of human normal seminal vesicles and may play an important role in the ejection of sperm plasm.
Similar content being viewed by others
References
LPJ Ooi DHG Crawford DC Gotley AD Clouston RW Strong GC Gobe JW Halliday KR Bridle GA Ramm (1997) ArticleTitleEvidence that “myofibroblast-like” cells are the cellular source of capsular collagen in hepatocellular carcinoma J Hepatol 26 798–807 Occurrence Handle9126792 Occurrence Handle10.1016/S0168-8278(97)80245-0 Occurrence Handle1:STN:280:ByiB2s7psVM%3D
H Chauhan A Abraham RA Phillips JH Pringle RA Walker JL Jones (2003) ArticleTitleThere is more than one kind of myofibroblasts: analysis of CD34 expression in benign, in situ, and invasive breast lesions J Clin Pathol 56 271–276 Occurrence Handle12663638 Occurrence Handle10.1136/jcp.56.4.271 Occurrence Handle1:STN:280:DC%2BD3s7nslKhug%3D%3D
PJ Barth T Schenck zu Schweinsberg A Ramaswamy R Moll (2004) ArticleTitleCD34(+) fibrocytes, α-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stoma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx Virchows Arch 444 231–234 Occurrence Handle14758552 Occurrence Handle10.1007/s00428-003-0965-1 Occurrence Handle1:CAS:528:DC%2BD2cXitFWrtrw%3D
M Illemann U Hansen HJ Nielsen PA Anderson G Hoyer-Hansen LR Lund K Dano BS Nielsen (2004) ArticleTitleLeading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1 Am J Clin Pathol 122 256–265 Occurrence Handle15323143 Occurrence Handle10.1309/F32X-WQ20-T568-H8VP Occurrence Handle1:CAS:528:DC%2BD2cXmvF2htL8%3D
N Kuroda M Toi H Nakayama E Miyazaki M Yamamoto Y Hayashi M Hi H Enzan (2004) ArticleTitleThe distribution and role of myofibroblasts and CD-34 positive stromal cells in normal pancreas and various pancreatic lesions Histol Histopathol 19 59–67 Occurrence Handle14702172 Occurrence Handle1:STN:280:DC%2BD2c%2FgsVyitw%3D%3D
R Lagace JA Grimaud W Schurch TR Seemayer (1985) ArticleTitleMyofibroblastic stromal reaction in carcinoma of the breast: variations of collagenous matrix and structural glycoprotein Virchows Arch Pathol Anat 408 49–59 Occurrence Handle10.1007/BF00739962 Occurrence Handle1:STN:280:BimD2crotFw%3D
N Shimasaki N Kuroda E Miyazaki Y Hayashi M Toi M Hiroi H Enzan T Shuin (2006) ArticleTitleThe distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness Histol Histopathol 21 349–353 Occurrence Handle16437379 Occurrence Handle1:STN:280:DC%2BD28%2FltVKqtg%3D%3D
PJ Barth A Ramaswamy R Moll (2002) ArticleTitleCD34(+) fibrocytes in normal cervical stroma, cervical intraepithelial neoplasia III, and invasive squamous cell carcinoma of the cervix uteri Virchows Arch 441 564–568 Occurrence Handle12461613 Occurrence Handle10.1007/s00428-002-0713-y
T Hamauzu N Kuroda L Guo E Miyazaki Y Hayashi M Toi M Hiroi H Enzan (2006) ArticleTitleCAM5.2-positive subserosal myofibroblasts in appendicitis Med Mol Morphol 39 IssueID4 209–213 Occurrence Handle17187184 Occurrence Handle10.1007/s00795-006-0332-9 Occurrence Handle1:CAS:528:DC%2BD28XhtlGitbnK
N Kuroda H Tada J Takahashi M Ohara T Hirouchi K Mizuno E Miyazaki H Enzan (2006) ArticleTitleMyofibroblasts in the stroma of metastatic pulmonary calcification in a patient with chronic renal failure Med Mol Morphol 39 IssueID3 161–163 Occurrence Handle16998627 Occurrence Handle10.1007/s00795-006-0329-4
N Kuroda H Nakayama E Miyazaki Y Hayashi M Toi M Hiroi H Enzan (2004) ArticleTitleDistribution and role of CD34-positive stromal cells and myofibroblasts in human normal testicular stroma Histol Histopathol 19 743–751 Occurrence Handle15168336 Occurrence Handle1:STN:280:DC%2BD2c3mvVSrsg%3D%3D
N Ueki K Sobue K Kanda T Hada K Higashino (1987) ArticleTitleExpression of high and low molecular weight caldesmons during phenotypic modulation of smooth muscle cells Proc Natl Acad Sci U S A 84 9040–9053 Occurrence Handle10.1073/pnas.84.24.9049
KM Ceballos GP Nielsen MK Selig JX O'Connell (2000) ArticleTitleIs anti-h-caldesmon useful for distinguishing smooth muscle and myofibroblastic tumors? Am J Surg Pathol 114 746–753 Occurrence Handle1:STN:280:DC%2BD3crht1amtA%3D%3D
K Watanabe T Tajiro M Sekiguchi T Suzuki (2000) ArticleTitleH-caldesmon as a specific marker for smooth muscle tumors: comparison with other smooth muscle markers in bone tumors Am J Clin Pathol 113 663–668 Occurrence Handle10800398 Occurrence Handle1:STN:280:DC%2BD3c3mtVWqsA%3D%3D
DS Rush JY Tan RN Baergen RA Soslow (2001) ArticleTitleH-caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrioid stromal sarcoma Am J Surg Pathol 25 253–258 Occurrence Handle11176075 Occurrence Handle10.1097/00000478-200102000-00014 Occurrence Handle1:STN:280:DC%2BD3M7ksVehsw%3D%3D
W Schurch TA Seemayer G Gabbiani (1998) ArticleTitleThe myofibroblast. A quarter century after its discovery Am J Surg Pathol 22 141–147 Occurrence Handle9500214 Occurrence Handle10.1097/00000478-199802000-00001 Occurrence Handle1:STN:280:DyaK1c7lvFymsg%3D%3D
J Kim D Cole A Johnson V Centenera E Schenkmen J Durham A Azzaro M Mawhinney (2002) ArticleTitleAndrogen induced norepinephrine release from postganglionic neurons mediates accessory sex organ smooth muscle proliferation J Urol 167 1897–1904 Occurrence Handle11912456 Occurrence Handle10.1016/S0022-5347(05)65257-3 Occurrence Handle1:CAS:528:DC%2BD38XislOmtrY%3D
S Jonathan C Iris F Bernard Z Horst G David (1992) ArticleTitleCystosarcoma phyllodes of the seminal vesicle Cancer (Phila) 71 2055–2061
L Pekka L Ilmo M Heikki R Mirja M Markku (1992) ArticleTitleMullerian adenosarcoma-like tumor of the seminal vesicle Arch Pathol Lab Med 116 1072–1076
S Hyun-Jin J Yeon-Jun K Jong-Hun C Myoung-Ja (2004) ArticleTitlePhyllodes tumor of the seminal vesicle: case report and literature review Pathol Int 54 924–929 Occurrence Handle10.1111/j.1440-1827.2004.01779.x
AS Marcos M Alexandre CWA Maria SP Catarina (1999) ArticleTitleExpression and pharmacological characterization of α1-adrenoceptors in rat seminal vesicle Eur J Pharmacol 381 141–149 Occurrence Handle10.1016/S0014-2999(99)00563-4
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shimasaki, N., Kuroda, N., Miyazaki, E. et al. Distribution and role of myofibroblasts in human normal seminal vesicle stroma. Med Mol Morphol 40, 208–211 (2007). https://doi.org/10.1007/s00795-007-0378-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00795-007-0378-3