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In situ production of sex steroids in human breast carcinoma

  • SPECIAL REVIEW SERIES: Carcinogenesis of breast carcinoma and its development
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Abstract

It is well known that sex steroids are closely involved in the growth of human breast carcinomas, and the great majority of breast carcinomas express sex steroid receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced and act in breast carcinoma tissues without release into plasma. Blockade of intratumoral estrogen production potentially leads to an improvement in the prognosis of invasive breast carcinoma patients, and, therefore, it is important to obtain a better understanding of sex steroid-producing enzymes in breast carcinoma. In this review, we summarize recent studies on tissue concentration of sex steroids and expression of enzymes related to intratumoral production of estrogens [aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1)], and androgens (17βHSD5 and 5α-reductase) in invasive and in situ (noninvasive) breast carcinomas, and discuss the significance of intratumoral production of sex steroids in breast carcinoma.

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Authors and Affiliations

  1. Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Takashi Suzuki, Yasuhiro Miki, Takuya Moriya, Jun-ichi Akahira & Hironobu Sasano

  2. Department of Surgery, Tohoku Kosai Hospital, Sendai, Japan

    Hisashi Hirakawa

  3. Department of Surgical Oncology, Tohoku University School of Medicine, Sendai, Japan

    Noriaki Ohuchi

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  2. Yasuhiro Miki
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  3. Takuya Moriya
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  4. Jun-ichi Akahira
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  7. Hironobu Sasano
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Correspondence to Takashi Suzuki.

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Suzuki, T., Miki, Y., Moriya, T. et al. In situ production of sex steroids in human breast carcinoma. Med Mol Morphol 40, 121–127 (2007). https://doi.org/10.1007/s00795-007-0365-8

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  • DOI: https://doi.org/10.1007/s00795-007-0365-8

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