Skip to main content

Advertisement

SpringerLink
Log in

Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP)

  • SPECIAL REVIEW SERIES: New ultrastructural discoveries in the pathophysiology of liver diseases
  • Published:
Medical Molecular Morphology Aims and scope Submit manuscript

Abstract

Liver transplantation has been considered as a promising therapy to halt the progression of clinical symptoms in familial amyloidotic polyneuropathy (FAP) because most transthyretin (TTR) is produced by the liver. In addition, domino liver transplantation using an FAP patient’s liver has been performed because of a shortage of donor livers. However, because the use of liver transplantation as therapy for FAP has given rise to several problems, an alternative treatment is needed. We have tried several other approaches. Recent studies suggested that certain metal ions affect amyloidogenesis. Among metal ions tested in an in vitro amyloid formation study, Cr3+ increased stability of both normal and mutant TTR tetramers and suppressed TTR amyloidogenesis induced by low pH. Our findings indicate that Cr3+ acts to suppress TTR amyloidogenesis. BSB, a Congo red derivative that binds to amyloid fibrils in FAP as well as to those in senile plaques in Alzheimer’s disease, effectively suppressed TTR amyloid formation in vitro. BSB may thus be useful for preventing amyloid formation. Free radical scavenger therapy was also tried in FAP patients but yielded no conclusive results. Immunization for transgenic mice having the ATTR V30M gene using ATTR Y78P resulted in suppression of amyloid deposits. Finally, an RNA/DNA chimera and single-stranded oligonucleotides (SSOs) were tested in vitro and in vivo in an attempt to repair the amyloidogenic TTR gene in the liver and retina. On the basis of results achieved so far, SSO is a promising tool for gene therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C Andrade (1952) ArticleTitleA peculiar form of peripheral neuropathy: familial generalized amyloidosis with special involvement of the peripheral nerves Brain 75 408–427 Occurrence Handle12978172

    PubMed  Google Scholar 

  2. S Araki (1984) ArticleTitleType I familial amyloidotic polyneuropathy (Japanese type) Brain Dev 6 128–133 Occurrence Handle6087691

    PubMed  Google Scholar 

  3. MD Benson (1989) ArticleTitleFamilial amyloidotic polyneuropathy Trends Neurosci 12 88–92 Occurrence Handle10.1016/0166-2236(89)90162-8 Occurrence Handle2469222

    Article  PubMed  Google Scholar 

  4. MD Benson T Uemichi (1996) ArticleTitleTransthyretin amyloidosis Amyloid Int J Clin Invest 3 44–56

    Google Scholar 

  5. Y Ando S Araki M Ando (1993) ArticleTitleTransthyretin related amyloidosis Intern Med 32 920–922 Occurrence Handle8204970

    PubMed  Google Scholar 

  6. Y Ando O Suhr (1998) ArticleTitleAutonomic dysfunction in familial amyloidotic polyneuropathy (FAP) Amyloid 5 288–300 Occurrence Handle10036588

    PubMed  Google Scholar 

  7. G Holmgren BG Ericzon CG Groth L Steen O Suhr O Andersen BG Wallin A Seymour S Richardson PN Hawkins MB Pepys (1993) ArticleTitleClinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis Lancet 341 113–116 Occurrence Handle10.1016/0140-6736(93)93127-M

    Article  Google Scholar 

  8. BG Ericzon G Holmgren E Lundgren OB Suhr (1999) ArticleTitleNew structural information and update on liver transplantation in transthyretin-associated amyloidosis. Report from the 4th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders & the 3rd International Workshop on Liver Transplantation in Familial Amyloid Polyneuropathy, Umea, Sweden Amyloid 7 145–147

    Google Scholar 

  9. M Skinner WD Lewis LA Jones J Kasirsky K Kane ST Ju R Jenkins RH Falk RW Simms AS Cohen (1994) ArticleTitleLiver transplantation as a treatment for familial amyloidotic polyneuropathy Ann Intern Med 120 133–134 Occurrence Handle8256972

    PubMed  Google Scholar 

  10. Y Takei S Ikeda Y Hashikura T Ikegami S Kawasaki (1999) ArticleTitlePartial-liver transplantation to treat familial amyloid polyneuropathy: follow-up of 11 patients Ann Intern Med 131 592–595 Occurrence Handle10523220

    PubMed  Google Scholar 

  11. Y Ando Y Tanaka E Ando T Yamashita Y Nishida K Tashima M Suga M Uchino M Ando (1995) ArticleTitleEffect of liver transplantation on autonomic dysfunction in familial amyloidotic polyneuropathy type I Lancet 345 195–196 Occurrence Handle10.1016/S0140-6736(95)90201-5

    Article  Google Scholar 

  12. O Suhr A Danielsson A Rydh N Nyhlin SO Hietala L Steen (1996) ArticleTitleImpact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy Dig Dis Sci 41 1909–1914 Occurrence Handle10.1007/BF02093589 Occurrence Handle8888700

    Article  PubMed  Google Scholar 

  13. J Lendoire P Trigo H Aziz G Cueto Y Ando K Tashima PI Ohlsson K Cederquist G Holmgren OB Suhr (1999) ArticleTitleLiver transplantation in transthyretin familial amyloid polyneuropathy: first report from Argentina Amyloid 6 297–300 Occurrence Handle10611953

    PubMed  Google Scholar 

  14. Y Ando H Terazaki K Haraoka T Tajiri M Nakamura K Obayashi S Misumi S Shoji K Hata K Nakagawa T Ishizaki S Uemoto Y Inomata K Tanaka H Okabe (2002) ArticleTitlePresence of autoantibody against ATTRVal30Met after sequential liver transplantation Transplantation 73 674–675 Occurrence Handle10.1097/00007890-200203150-00002 Occurrence Handle11907408

    Article  PubMed  Google Scholar 

  15. E Ando Y Ando K Haraoka (2001) ArticleTitleOcular amyloid imvolvement after liver transplantation for polyneuropathy Ann Intern Med 135 931–932 Occurrence Handle11712896

    PubMed  Google Scholar 

  16. ML Sales-Luis M Galvao M Carvalho G Sousa MM Alves R Serrao (1991) ArticleTitleTreatment of familial amyloidotic polyneuropathy (Portuguese type) by plasma exchange Muscle Nerve 14 377–378 Occurrence Handle2027354

    PubMed  Google Scholar 

  17. P Continho E Macedo A Estacio A Saraiva PP Costa MJM Saraiva (1988) Periodic plasma exchanges in treatment of familial amyloid polyneuropathy: preliminary results T Isobe S Araki F Uchino S Kito E Tsubura (Eds) Amyloid and amyloidosis Plenum Press New York 845–849

    Google Scholar 

  18. S Ikegawa S Tanase Y Morino S Yi Y Ando A Miyazaki S Araki (1988) Evaluation of serum variant prealbumin levels, and its behavior after plasma exchange for familial amyloidotic polyneuropathy (type 1) T Isobe S Araki F Uchino S Kito E Tsubura (Eds) Amyloid and amyloidosis Plenum Press New York 839–844

    Google Scholar 

  19. V Regnault PM Costa A Teixeira C Rivat JF Stoltz MJ Saraiva PP Costa (1992) ArticleTitleSpecific removal of transthyretin from plasma of patients with familial amyloidotic polyneuropathy: optimization of an immunoadsorption procedure Int J Artif Organs 15 249–255 Occurrence Handle1316882

    PubMed  Google Scholar 

  20. PMP Costa PP Costa (1998) ArticleTitleThe future of selective apheresis in FAP Amyloid 5 143–144 Occurrence Handle9686308

    PubMed  Google Scholar 

  21. T Tokuda T Kondo N Hanaoka Y Takei F Kametani Y Yamada Y Tamura M Yoshida N Yamawaki S Ikeda (1998) ArticleTitleA selective transthyretin-adsorption column for the treatment of patients with familial amyloid polyneuropathy Amyloid 5 111–116 Occurrence Handle9686305

    PubMed  Google Scholar 

  22. J Jouquan Y Pennec D Mottier JM Boles JF Morin P Youinou M Garre (1983) ArticleTitleRetinol carrier protein, prealbumin and transferrin. Influence of age and sex on the serum concentration of proteins with a short half-life Presse Med 12 1877

    Google Scholar 

  23. PW Dickson GJ Howlett G Schreiber (1982) ArticleTitleMetabolism of prealbumin in rats and changes induced by acute inflammation Eur J Biochem 129 289–293 Occurrence Handle10.1111/j.1432-1033.1982.tb07051.x Occurrence Handle7151801

    Article  PubMed  Google Scholar 

  24. Y Ando Y Tanaka M Nakazato BG Ericzon T Yamashita K Tashima N Sakashita M Suga M Uchino M Ando (1995) ArticleTitleChange in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation Biochem Biophys Res Commun 211 354–358 Occurrence Handle10.1006/bbrc.1995.1820 Occurrence Handle7794243

    Article  PubMed  Google Scholar 

  25. M Skinner WD Lewis LA Jones J Kasirsky K Kane ST Ju R Jenkins RH Falk RW Simms AS Cohen (1994) ArticleTitleLiver transplantation as a treatment for familial amyloidotic polyneuropathy Ann Intern Med 120 133–134 Occurrence Handle8256972

    PubMed  Google Scholar 

  26. Y Ando Y Tanaka M Nakazato BG Ericzon T Yamashita K Tashima N Sakashita M Suga M Uchino M Ando (1995) ArticleTitleChange in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation Biochem Biophys Res Commun 211 354–358 Occurrence Handle10.1006/bbrc.1995.1820 Occurrence Handle7794243

    Article  PubMed  Google Scholar 

  27. E Monteiro R Perdigoto AL Furtado (1998) ArticleTitleLiver transplantation for familial amyloid polyneuropathy Hepatogastroenterology 45 1375–1380 Occurrence Handle9840068

    PubMed  Google Scholar 

  28. M Golling R Singer G Weiss A Mehrabi C Zapletal T Kraus C Herfarth E Klar (2000) ArticleTitleSequential (domino) transplantation of the liver in a transthyretin-50 familial amyloid polyneuropathy. Special reference to cardiological diagnosis and complications Langenbecks Arch Surg 385 21–26 Occurrence Handle10.1007/s004230050005 Occurrence Handle10664115

    Article  PubMed  Google Scholar 

  29. JW Kelly Lansbury PT SuffixJr (1994) ArticleTitleA chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid formation Amyloid 1 186–205

    Google Scholar 

  30. W Colon JW Kelley (1992) ArticleTitlePartial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro Biochemistry 31 8654–8660 Occurrence Handle10.1021/bi00151a036 Occurrence Handle1390650

    Article  PubMed  Google Scholar 

  31. SL McCutchen W Colon JW Kelley (1993) ArticleTitleTransthyretin mutation Leu-55-Pro alters tetrameric stability and increases amyloidogenicity Biochemistry 32 12119–12127 Occurrence Handle10.1021/bi00096a024 Occurrence Handle8218290

    Article  PubMed  Google Scholar 

  32. IL Alves CM Divino GC Schussler K Altland MR Almeida JA Palha T Coelho PP Costa MJ Saraiva (1993) ArticleTitleThyroxine binding in a TTR Met 119 kindred J Clin Endocrinol Metab 77 484–488 Occurrence Handle10.1210/jc.77.2.484 Occurrence Handle8102146

    Article  PubMed  Google Scholar 

  33. I Longo Alves MT Hays MJ Saraiva (1997) ArticleTitleComparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin Eur J Biochem 249 662–668 Occurrence Handle10.1111/j.1432-1033.1997.00662.x Occurrence Handle9395311

    Article  PubMed  Google Scholar 

  34. MR Almeida AM Damas MC Lans A Brouwer MJ Saraiva (1997) ArticleTitleThyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis Endocrine 6 309–315 Occurrence Handle9368688

    PubMed  Google Scholar 

  35. H Terazaki Y Ando S Misumi M Nakamura E Ando N Matsunaga S Shoji M Okuyama H Ideta K Nakagawa T Ishizaki M Ando MJ Saraiva (1999) ArticleTitleA novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels Biochem Biophys Res Commun 264 365–370 Occurrence Handle10.1006/bbrc.1999.1514 Occurrence Handle10529370

    Article  PubMed  Google Scholar 

  36. MR Almeida IL Alves H Terazaki Y Ando MJ Saraiva (2000) ArticleTitleComparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M Biochem Biophys Res Commun 270 1024–1028 Occurrence Handle10.1006/bbrc.2000.2554 Occurrence Handle10772944

    Article  PubMed  Google Scholar 

  37. PW Baures VB Oza SA Peterson JW Kelly (1999) ArticleTitleSynthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid Bioorg Med Chem 7 1339–1347 Occurrence Handle10.1016/S0968-0896(99)00066-8 Occurrence Handle10465408

    Article  PubMed  Google Scholar 

  38. SA Peterson T Klabunde HA Lashuel H Purkey JC Sacchettini JW Kelly (1998) ArticleTitleInhibiting transthyretin conformational changes that lead to amyloid fibril formation Proc Natl Acad Sci USA 95 12956–12960 Occurrence Handle10.1073/pnas.95.22.12956 Occurrence Handle9789022

    Article  PubMed  Google Scholar 

  39. Mikami F, Ando Y, Imasato A, Tajiri T, Sato T, Shuto T, Kai H (2002) Transthyretin amyloidogenesis altered by Cr3+ and Al3+. 5th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders I-P-04 (abstract)

  40. CD Guy CK Jones (2001) ArticleTitleAbdominal fat pad aspiration biopsy for tissue confirmation of systemic amyloidosis: specificity, positive predictive value, and diagnostic pitfalls Diagn Cytopathol 24 181–185 Occurrence Handle10.1002/1097-0339(200103)24:3<181::AID-DC1037>3.0.CO;2-D Occurrence Handle11241901

    Article  PubMed  Google Scholar 

  41. B Kaplan R Vidal A Kumar J Ghiso G Gallo (1999) ArticleTitleImmunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat Am J Clin Pathol 112 403–407 Occurrence Handle10478147

    PubMed  Google Scholar 

  42. I Masouye (1997) ArticleTitleDiagnostic screening of systemic amyloidosis by abdominal fat aspiration: an analysis of 100 cases Am J Dermatopathol 19 41–45 Occurrence Handle10.1097/00000372-199702000-00008 Occurrence Handle9056653

    Article  PubMed  Google Scholar 

  43. GT Westermark P Westermark (2000) ArticleTitleEndocrine amyloid – a subject of increasing interest for the next century Amyloid 7 19–22 Occurrence Handle10842700

    PubMed  Google Scholar 

  44. PN Hawkins JP Lavender MB Pepys (1990) ArticleTitleEvaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component N Engl J Med 323 508–513 Occurrence Handle2377176

    PubMed  Google Scholar 

  45. M Puille K Altland RP Linke MK Steen-Muller R Klett D Steiner R Bauer (2002) ArticleTitle99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy Eur J Nucl Med 29 376–379 Occurrence Handle10.1007/s00259-001-0730-0

    Article  Google Scholar 

  46. M Giger HR Baumgartner G Zbinden (1974) ArticleTitleToxicological effects of Evans blue and Congo red on blood platelets Agents Actions 4 173–180 Occurrence Handle10.1007/BF01970259 Occurrence Handle4416679

    Article  PubMed  Google Scholar 

  47. WE Klunk ML Debnath JW Pettegrew (1995) ArticleTitleChrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe Neurobiol Aging 16 541–548 Occurrence Handle10.1016/0197-4580(95)00058-M Occurrence Handle8544903

    Article  PubMed  Google Scholar 

  48. WE Klunk ML Debnath AM Koros JW Pettegrew (1998) ArticleTitleChrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells Life Sci 63 1807–1814 Occurrence Handle10.1016/S0024-3205(98)00454-8 Occurrence Handle9820124

    Article  PubMed  Google Scholar 

  49. NA Dezutter RM Sciot TJ de Groot GM Bormans AM Verbruggen (2001) ArticleTitleIn vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis Nucl Med Commun 22 553–558 Occurrence Handle10.1097/00006231-200105000-00014 Occurrence Handle11388578

    Article  PubMed  Google Scholar 

  50. NA Dezutter WJ Landman PL Jager TJ de Groot PJ Dupont PC Tooten B Zekarias E Gruys AM Verbruggen (2001) ArticleTitleEvaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis Amyloid 8 202–214 Occurrence Handle11676297

    PubMed  Google Scholar 

  51. NA Dezutter RJ Dom TJ de Groot GM Bormans AM Verbruggen (1999) ArticleTitle99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer’s disease Eur J Nucl Med 26 1392–1399 Occurrence Handle10.1007/s002590050470 Occurrence Handle10552079

    Article  PubMed  Google Scholar 

  52. DM Skovronsky B Zhang MP Kung HF Kung JQ Trojanowski VM Lee (2000) ArticleTitleIn vivo detection of amyloid plaques in a mouse model of Alzheimer’s disease Proc Natl Acad Sci USA 97 7609–7614 Occurrence Handle10.1073/pnas.97.13.7609 Occurrence Handle10861023

    Article  PubMed  Google Scholar 

  53. ML Schmidt T Schuck S Sheridan MP Kung H Kung ZP Zhuang C Bergeron JS Lamarche D Skovronsky BI Giasson VM Lee JQ Trojanowski (2001) ArticleTitleThe fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains Am J Pathol 159 937–943 Occurrence Handle11549586

    PubMed  Google Scholar 

  54. WE Klunk ML Debnath JW Pettegrew (1994) ArticleTitleDevelopment of small molecule probes for the beta-amyloid protein of Alzheimer’s disease Neurobiol Aging 15 691–698 Occurrence Handle10.1016/0197-4580(94)90050-7 Occurrence Handle7891823

    Article  PubMed  Google Scholar 

  55. ZP Zhuang MP Kung C Hou K Plossl D Skovronsky TL Gur JQ Trojanowski VM Lee HF Kung (2001) ArticleTitleIBOX(2-(4′-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain Nucl Med Biol 28 887–894 Occurrence Handle10.1016/S0969-8051(01)00264-5 Occurrence Handle11711307

    Article  PubMed  Google Scholar 

  56. Y Okahata K Niikura Y Sugiura M Sawada T Morii (1998) ArticleTitleKinetic studies of sequence-specific binding of GCN4-bZIP peptides to DNA strands immobilized on a 27-MHz quartz-crystal microbalance Biochemistry 37 5666–5672 Occurrence Handle10.1021/bi980037k Occurrence Handle9548952

    Article  PubMed  Google Scholar 

  57. H Matsuno K Niikura Y Okahata (2001) ArticleTitleDirect monitoring kinetic studies of DNA polymerase reactions on a DNA-immobilized quartz-crystal microbalance Chemistry 7 3305–3312 Occurrence Handle10.1002/1521-3765(20010803)7:15<3305::AID-CHEM3305>3.0.CO;2-Y Occurrence Handle11531116

    Article  PubMed  Google Scholar 

  58. G Merlini E Ascari N Amboldi V Bellotti E Arbustini V Perfetti M Ferrari I Zorzoli MG Marinone P Garini M Diegori D Trizio D Ballinari (1995) ArticleTitleInteraction of the anthracycline 4′-iodo-4′-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis Proc Natl Acad Sci USA 92 2959–2963 Occurrence Handle7708755

    PubMed  Google Scholar 

  59. MA Gertz MQ Lacy A Dispenzieri BD Cheson B Barlogie RA Kyle G Palladini SM Geyer G Merlini (2002) ArticleTitleA multicenter phase II trial of 4′-iodo-4′-deoxydoxorubicin (IDOX) in primary amyloidosis (AL Amyloid 9 24–30 Occurrence Handle12000194

    PubMed  Google Scholar 

  60. MP Sebastiao G Merlini MJ Saraiva AM Damas (2000) ArticleTitleThe molecular interaction of 4′-iodo-4′-deoxydoxorubicin with Leu-55Pro transthyretin “amyloid-like” oligomer leading to disaggregation Biochem J 351 273–279 Occurrence Handle10.1042/0264-6021:3510273 Occurrence Handle10998371

    Article  PubMed  Google Scholar 

  61. JM McCord (1980) ArticleTitleOxygen free radicals: Release and activities Agents Actions 10 522–527 Occurrence Handle10.1007/BF02024157 Occurrence Handle6267912

    Article  PubMed  Google Scholar 

  62. M Hirota M Inoue Y Ando K Hirayama Y Mirono K Sakamoto K Mori M Akagi (1989) ArticleTitleInhibition of stress induced gastric injury in the rat by glutathione Gastroenterology 97 853–859 Occurrence Handle2777041

    PubMed  Google Scholar 

  63. E Ando Y Ando R Kamata M Inoue Y Morino R Okamura (1990) ArticleTitleInhibition of corneal inflammation by an acylated superoxide dismutase derivation Invest Ophthalmol Vis Sci 31 1963–1967 Occurrence Handle2210992

    PubMed  Google Scholar 

  64. Y Ando S Ikegawa A Miyazaki M Inoue Y Morino S Araki (1989) ArticleTitleRole of variant prealbumin in the pathogenesis of familial amyloidotic polyneuropathy: rate of normal and variant prealbumin in circulation Arch Biochem Biophys 274 87–92 Occurrence Handle10.1016/0003-9861(89)90418-9 Occurrence Handle2774586

    Article  PubMed  Google Scholar 

  65. D Granger (1988) ArticleTitleRole of xanthine oxidase and granulocytes in ischemia-reperfusion injury Am J Physiol 255 H1269–H1275 Occurrence Handle3059826

    PubMed  Google Scholar 

  66. InstitutionalAuthorNameThe Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group (1994) ArticleTitleThe effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers N Engl J Med 330 1029–1035

    Google Scholar 

  67. BL Banwell AG Engel (2000) ArticleTitleAlphaB-crystallin immunolocalization yields new insights into inclusion body myositis Neurology 54 1033–1041 Occurrence Handle10720271

    PubMed  Google Scholar 

  68. MP Mattson B Cheng D Davis K Bryant I Lieberburg RE Rydel (1992) ArticleTitleβ-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity J Neurosci 12 376–389 Occurrence Handle1346802

    PubMed  Google Scholar 

  69. C Capeillere-Blandin T Delaveau B Descamps-Latscha (1991) ArticleTitleStructural modifications of human beta 2 microglobulin treated with oxygen-derived radicals Biochem J 277 175–182 Occurrence Handle1649598

    PubMed  Google Scholar 

  70. S Toyokuni K Uchida K Okamoto Y Hattori-Nakakuki H Hiai ER Stadtman (1994) ArticleTitleFormation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate Proc Natl Acad Sci USA 91 2616–2620 Occurrence Handle8146163

    PubMed  Google Scholar 

  71. RJ Mark MA Lovell WR Markesbery K Uchida MP Mattson (1997) ArticleTitleA role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide J Neurochem 68 255–264 Occurrence Handle8978733

    PubMed  Google Scholar 

  72. Y Sagara R Dargusch FG Klier D Schubert C Behl (1996) ArticleTitleIncreased antioxidant enzyme activity in amyloid β protein-sresistant cells J Neurosci 16 497–505 Occurrence Handle8551334

    PubMed  Google Scholar 

  73. M Skinner P Stone T Shirahama L Connors J Calore A Cohen (1986) ArticleTitleThe association of an elastase with amyloid fibrils Proc Soc Exp Biol Med 181 211–214 Occurrence Handle3633118

    PubMed  Google Scholar 

  74. P Stone J Camistol CR Abraham O Rodgers T Shirahama M Skinner (1993) ArticleTitleNeutrophil proteases associated with amyloid fibrils Biochem Biophys Res Commun 30 130–136 Occurrence Handle10.1006/bbrc.1993.2451

    Article  Google Scholar 

  75. A Benedetti M Comporti H Esterbauer (1980) ArticleTitleIdentification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids Biochim Biophys Acta 620 281–296 Occurrence Handle6254573

    PubMed  Google Scholar 

  76. W Siems J Kowalewski A Werner I Schimke G Gerber (1989) ArticleTitleRadical formation in the rat small intestine during and following ischemia Free Radic Res Commun 7 347–353 Occurrence Handle2583551

    PubMed  Google Scholar 

  77. K Uchida K Itakura S Kawakishi H Hiai S Toyokuni ER Stadtman (1995) ArticleTitleCharacterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies Arch Biochem Biophys 324 241–248 Occurrence Handle10.1006/abbi.1995.0036 Occurrence Handle8554315

    Article  PubMed  Google Scholar 

  78. Y Ando T Brännström K Uchida N Nyhlin B Näsman O Suhr T Yamashita T Olsson M Uchino M Ando (1998) ArticleTitleHistochemical detection of 4-hydroxynonenal protein in Alzheimer disease amyloid J Neurol Sci 156 172–176 Occurrence Handle10.1016/S0022-510X(98)00042-2 Occurrence Handle9588853

    Article  PubMed  Google Scholar 

  79. HF Hoff JA O’Neil (1991) ArticleTitleOxidation of LDL: role in atherogenesis Klin Wochenschr 69 1032–1038 Occurrence Handle10.1007/BF01645153 Occurrence Handle1798276

    Article  PubMed  Google Scholar 

  80. N Sakashita Y Ando K Jinnouchi M Yoshimatsu H Terazaki K Obayashi M Takeya (2001) ArticleTitleFamilial amyloidotic polyneuropathy (ATTR Val30Met) with widespread cerebral amyloid angiopathy and lethal cerebral hemorrhage Pathol Int 51 476–480 Occurrence Handle10.1046/j.1440-1827.2001.01228.x Occurrence Handle11422811

    Article  PubMed  Google Scholar 

  81. Y Ando N Nyhlin O Suhr G Holmgren K Uchida M El-Salhy T Yamashita H Terasaki M Nakamura M Uchino M Ando (1997) ArticleTitleOxidative stress is found in amyloid deposits in systemic amyloidosis Biochem Biophys Res Commun 232 497–502 Occurrence Handle10.1006/bbrc.1996.5997 Occurrence Handle9125209

    Article  PubMed  Google Scholar 

  82. Y Ando O Suhr M El-Salhy (1998) ArticleTitleOxidative stress and amyloidosis Histol Histopathol 13 845–850 Occurrence Handle9690141

    PubMed  Google Scholar 

  83. N Nyhlin Y Ando R Nagai O Suhr M El-Salhy H Terazaki Yamashita M Ando S Horiuchi (2000) ArticleTitleAdvanced glycation end product in familial amyloidotic polyneuropathy (FAP) J Intern Med 247 485–492 Occurrence Handle10.1046/j.1365-2796.2000.00668.x Occurrence Handle10792563

    Article  PubMed  Google Scholar 

  84. N Sakashita Y Ando SL Marklund K Tashima P Nilsson T Yamashita M Takeya K Takahashi (1998) ArticleTitleFamilial amyloidotic polyneuropathy type I with extracellular superoxide dismutase mutation: a case report Hum Pathol 13 845–850

    Google Scholar 

  85. OB Suhr K Lang L Wikstrom I Anan Y Ando M El-Salhy G Holmgren K Tashima (2001) ArticleTitleScavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients Scand J Clin Lab Invest 61 11–18 Occurrence Handle11300606

    PubMed  Google Scholar 

  86. MJ Propsting M Blaschke RE Haas J Genschel HJ Hedrich MP Manns HH Schmidt (1999) ArticleTitleInosine(15.1)-hammerhead ribozymes for targeting the transthyretin-30 mutation Biochem Biophys Res Commun 260 313–317 Occurrence Handle10.1006/bbrc.1999.0906 Occurrence Handle10403767

    Article  PubMed  Google Scholar 

  87. K Tanaka T Yamada Y Ohyagi H Asahara I Horiuchi J Kira (2001) ArticleTitleSuppression of transthyretin expression by ribozymes: a possible therapy for familial amyloidotic polyneuropathy J Neurol Sci 183 79–84 Occurrence Handle10.1016/S0022-510X(00)00481-0 Occurrence Handle11166799

    Article  PubMed  Google Scholar 

  88. K Yoon A Cole-Strauss EB Kmiec (1996) ArticleTitleTargeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA·DNA oligonucleotide Proc Natl Acad Sci USA 93 2071–2076 Occurrence Handle10.1073/pnas.93.5.2071 Occurrence Handle8700887

    Article  PubMed  Google Scholar 

  89. A Cole-Strauss K Yoon Y Xiang BC Byrne MC Rice J Gryn WK Holloman EB Kmiec (1996) ArticleTitleCorrection of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide Science 273 1386–1389 Occurrence Handle8703073

    PubMed  Google Scholar 

  90. BT Kren A Cole-Strauss EB Kmiec CJ Steer (1997) ArticleTitleTargeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide Hepatology 25 1462–1468 Occurrence Handle10.1002/hep.510250626 Occurrence Handle9185769

    Article  PubMed  Google Scholar 

  91. Y Xiang A Cole-Strauss K Yoon J Gryn EB Kmiec (1997) ArticleTitleTargeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide J Mol Med 75 829–835 Occurrence Handle10.1007/s001090050172 Occurrence Handle9428613

    Article  PubMed  Google Scholar 

  92. BT Kren P Bandyopadhyay CJ Steer (1998) ArticleTitleIn vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotide Nat Med 4 285–290 Occurrence Handle10.1038/nm0398-285 Occurrence Handle9500600

    Article  PubMed  Google Scholar 

  93. V Alexeev K Yoon (1998) ArticleTitleStable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA/DNA oligonucleotide Nat Biotechno 1 IssueID16 1343–1346

    Google Scholar 

  94. BT Kren B Parashar P Bandyopadhyay N Chowdhury JR Chowdhury CJ Steer (1999) ArticleTitleCorrection of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler-Najjar syndrome type I with a chimeric oligonucleotide Proc Natl Acad Sci USA 96 10349–10354 Occurrence Handle10.1073/pnas.96.18.10349 Occurrence Handle10468611

    Article  PubMed  Google Scholar 

  95. Gamper HB SuffixJr A Cole-Strauss R Metz H Parekh R Kumar EB Kmiec (2000) ArticleTitleA plausible mechanism for gene correction by chimeric oligonucleotides Biochemistry 39 5808–5816 Occurrence Handle10.1021/bi9921891 Occurrence Handle10801331

    Article  PubMed  Google Scholar 

  96. HB Gamper H Parekh MC Rice M Bruner H Youkey EB Kmiec (2000) ArticleTitleThe DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts Nucleic Acids Res 28 4332–4339 Occurrence Handle10.1093/nar/28.21.4332 Occurrence Handle11058133

    Article  PubMed  Google Scholar 

  97. M Kishikawa T Nakanishi A Miyazaki A Shimizu (1999) ArticleTitleEnhanced amyloidogenicity of sulfonated transthyretin in vitro, a hypothetical etiology of senile amyloidosis Amyloid 6 183–186 Occurrence Handle10524282

    PubMed  Google Scholar 

  98. K Altland P Winter (1999) ArticleTitlePotential treatment of transthyretin-type amyloidoses by sulfite Neurogenetics 2 183–188 Occurrence Handle10.1007/s100480050081 Occurrence Handle10541593

    Article  PubMed  Google Scholar 

  99. I Cardoso PJ Pereira AM Damas MJ Saraiva (2000) ArticleTitleAprotinin binding to amyloid fibrils Eur J Biochem 267 2307–2311 Occurrence Handle10.1046/j.1432-1327.2000.01237.x Occurrence Handle10759855

    Article  PubMed  Google Scholar 

  100. D Morgan DM Diamond PE Gottschall KE Ugen C Dickey J Hardy K Duff P Jantzen G DiCarlo D Wilcock K Connor J Hatcher C Hope M Gordon GW Arendash (2000) ArticleTitleA beta peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease Nature (Lond) 408 982–985 Occurrence Handle10.1038/35050116

    Article  Google Scholar 

  101. BP Imbimbo (2002) ArticleTitleToxicity of beta-amyloid vaccination in patients with Alzheimer’s disease Ann Neurol 51 794 Occurrence Handle10.1002/ana.10185

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-0811, Japan

    Yukio Ando

Authors
  1. Yukio Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yukio Ando.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ando, Y. Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP). Med Mol Morphol 38, 142–154 (2005). https://doi.org/10.1007/s00795-005-0288-1

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00795-005-0288-1

Key words

Search

Navigation