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Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study

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Abstract

Objectives

The aim of this study was to investigate the association between serum biomarkers and oral health parameters in children with chronic kidney disease (CKD).

Materials and methods

Serum hemoglobin, blood urea nitrogen, serum creatinine, calcium, parathormone, magnesium, and phosphorus levels were measured in 62 children with CKD aged between 4 and 17 years. Intraoral examinations of the patients were performed by two different pediatric dentists. Dental caries was assessed using the decayed-missing-filled-teeth (DMFT/dmft) indexes, and oral hygiene was assessed using the debris (DI), calculus (CI), and simplified oral hygiene (OHI-S) indexes. Spearman’s rho coefficient and generalized linear modeling were used to examine the association between serum biomarkers and oral health parameters.

Results

The results of the study showed that there were negative and statistically significant correlations between serum hemoglobin and creatinine levels and dmft scores in pediatric patients with CKD (p = 0.021 and p = 0.019, respectively). Furthermore, blood urea nitrogen levels and DI and OHI-S scores (p = 0.047 and p = 0.050, respectively); serum creatinine levels and DI, CI, and OHI-S scores (p = 0.005, p = 0.047, p = 0.043, respectively); and parathormone levels and CI and OHI-S scores (p = 0.001 and p = 0.017, respectively) were found to be positively and statistically significantly related.

Conclusions

There are associations between various serum biomarker levels and dental caries and oral hygiene parameters in pediatric patients with CKD.

Clinical relevance

The impact of changes in serum biomarkers on oral and dental health is important for dentists’ and medical professionals' approaches to patients' oral and systemic health.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Pediatric Dentistry, School of Dentistry, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye

    Berkant Sezer

  2. Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Türkiye

    Nur Kodaman Dokumacıgil, Remziye Kaya & Betül Kargül

  3. Division of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Türkiye

    Serçin Güven, Özde Nisa Türkkan, Neslihan Çiçek & Harika Alpay

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  1. Berkant Sezer
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  2. Nur Kodaman Dokumacıgil
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  8. Betül Kargül
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Contributions

Conceptualization: [Berkant Sezer], [Harika Alpay], [Betül Kargül]; Methodology: [Berkant Sezer], [Harika Alpay], [Betül Kargül]; Formal analysis and investigation: [Berkant Sezer], [Nur Kodaman Dokumacıgil], [Remziye Kaya], [Serçin Güven], [Özde Nisa Türkkan], [Neslihan Çiçek]; Writing—original draft preparation: [Berkant Sezer]; Writing—review and editing: [Berkant Sezer], [Serçin Güven], [Özde Nisa Türkkan], [Neslihan Çiçek], [Harika Alpay], [Betül Kargül]; Supervision: [Harika Alpay], [Betül Kargül].

Corresponding author

Correspondence to Berkant Sezer.

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Competing interests

The authors declare no competing interests.

Ethics approval

This cross-sectional study was approved by the Clinical Research Ethical Committee of the School of Medicine, Marmara University with a protocol number of 09.2021.290. The study was conducted in accordance with all the ethical principles of the Declaration of Helsinki.

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Patients included in the study and their parents or caregivers were informed about the study and signed informed consent forms.

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The authors declare no competing interests.

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Sezer, B., Kodaman Dokumacıgil, N., Kaya, R. et al. Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study. Clin Oral Invest 27, 3731–3740 (2023). https://doi.org/10.1007/s00784-023-04989-1

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