Abstract
Objective
Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact allergies to dental materials and oral hygiene products in these patients.
Methods
Forty-nine patients (7 men, 42 women) aged 31 to 77 years (61 ± 10.3 years) with symptomatic OLP, OLL or stomatitis and 29 healthy age- and gender-matched control subjects were included. They underwent an interview, clinical examination, oral mucosal biopsy and epicutan testing to the European baseline series, a toothpaste and dental material series.
Results
Nineteen patients had OLP, 19 OLL and 11stomatitis. Oral burning/itching was the most common symptom (83.7%), and 65.3% patients had more than one symptom. Patients visited their dentist more often than the healthy subjects and had statistically higher DMF-T and DMF-S scores. Nineteen patients (38.8%) and 10 healthy control subjects (34.5%) had allergic contact reactions primarily to fragrance ingredients. No differences could be found between OLP, OLL, stomatitis and healthy controls with regard to allergic contact reactions. However, contact allergy to aroma substances differed significantly between the patients and the healthy control subjects (p = 0.02). This type of contact allergy was most common in patients with OLP and OLL (p = 0.01). Avoidance cleared symptoms in all cases.
Conclusion/clinical relevance
Allergic reactions to aroma substances in oral hygiene products are common in patients with symptomatic OLP, OLL and stomatitis.
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Acknowledgements
We gratefully wish to thank laboratory technician Louise Rosgaard Duus for her assistance with the laboratory work, project nurse Anne Marie Topp for helping with the coordination of the participants and assistant professor Kasper Rosing for assistance with the statistical analyses.
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The authors declare that they have no conflicts of interest.
Funding
We gratefully thank the Faculty of Medical and Health Sciences, University of Copenhagen, the Danish Dental Association and Toyota Fonden, Denmark, for the financial support.
Ethical approval
The study was approved by the Regional Ethics Committee, Copenhagen, Denmark (Protocol No. H-3-2013-033) and performed in accordance with the Helsinki declaration.
Informed consent
The study participants were both informed by letter and gave oral and written consent.
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Appendix 1
Test-series and test components provided by Chemotechnique, Vellinge, Sweden if other is not indicated. Italics indicates overlapping of test series (DOCX 23 kb)
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Larsen, K., Johansen, J., Reibel, J. et al. Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products. Clin Oral Invest 21, 2543–2551 (2017). https://doi.org/10.1007/s00784-017-2053-y
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DOI: https://doi.org/10.1007/s00784-017-2053-y