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High HIF-1α expression genotypes in oral lichen planus

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Abstract

Objective

The aim of this study is to assess whether C1772T and G1790A hypoxia-inducible factor-1 (HIF-1)α polymorphisms are associated with risk of oral lichen planus (OLP).

Material and methods

Restriction fragment length polymorphism analysis was used to investigate HIF-1α C1779T and G1790A polymorphisms in 32 OLP and 88 individuals without OLP.

Results

The frequency of the CC, TT, GA, and AA genotypes was higher in patients with OLP. Notably, individuals carrying the C and A, and T and A haplotypes showed a significant association OLP risk.

Conclusions

Our study demonstrated that the C1772T and G1790A polymorphisms of HIF-1α gene increased the risk of OLP. C1772T and G1790A polymorphisms of HIF-1α gene had differing patterns of allelic imbalance in the normal samples and subsequent chronic lesions. Further studies are necessary to elucidate the HIF-1α pathway in OLP, which would facilitate the development of novel therapeutic strategies for the prevention and treatment of OLP.

Clinical relevance

These results, in conjunction with previous studies, suggest that HIF-1α may play important roles in the chronicity of oral mucosa lesions of OLP patients. Taken together, we suggest that HIF-1α polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP. It appears unlikely that inhibition of a single proinflammatory mediator will prove useful in clinical practice, but several ways to reprogram mediators engaged in a wide array of roles simultaneously are encouraging.

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Acknowledgments

This study was supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico and the Fundação de Amparo a Pesquisa do Estado de Minas Gerais. Dr Guimarães is a research fellow of CNPq. Dr De Paula is a research fellow of FAPEMIG.

Conflict of interest

No conflicts declared.

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Authors and Affiliations

  1. Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil

    Carlos Alberto de Carvalho Fraga, Lucas Rodrigues Alves, Luciano Marques-Silva, Adriana Alkmim de Sousa, Sabrina Ferreira de Jesus, Daniel Nogueira Vilela, Ugo Borges Pinheiro, Kimberly Marie Jones, Alfredo Maurício Batista de Paula & André Luiz Sena Guimarães

  2. Department of Medicine, Universidade Estadual de Montes Claros, Montes Claros, Brazil

    Antonio Sérgio Barcala Jorge

  3. Hospital Universitário Clemente de Faria, Avenida Cula Mangabeira, 562, Montes Claros, Minas Gerais, Brazil, 39400-000

    André Luiz Sena Guimarães

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  1. Carlos Alberto de Carvalho Fraga
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  2. Lucas Rodrigues Alves
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  3. Luciano Marques-Silva
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  4. Adriana Alkmim de Sousa
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  10. Alfredo Maurício Batista de Paula
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  11. André Luiz Sena Guimarães
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Correspondence to André Luiz Sena Guimarães.

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de Carvalho Fraga, C.A., Alves, L.R., Marques-Silva, L. et al. High HIF-1α expression genotypes in oral lichen planus. Clin Oral Invest 17, 2011–2015 (2013). https://doi.org/10.1007/s00784-013-0920-8

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  • DOI: https://doi.org/10.1007/s00784-013-0920-8

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