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Salivary constituents and acidogenic microbial counts in coronary artery bypass graft patients from baseline to three-years after operation

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Abstract

Data on saliva in coronary artery bypass graft (CABG) surgery patients are sparse. Understanding salivary parameters, however, may aid clinical decision making. We hypothesized that cardiac surgery might affect patients’ salivary flow rates and buffering, salivary proteins, and microbial counts. A 3-year, open follow-up study was conducted examining salivary flow, its chemical composition, and acidogenic microbial counts in 89 CABG surgery patients. The changes in salivary flow and proteins between baseline and 3-year post-CABG surgery were assessed using paired t-test and, with respect to the median of number of drugs used daily, by use of a nonparametric rank sum test. The results showed no long-term change in salivary flow rates and buffering capacity. With the exception of salivary urea, IgA and IgM concentration, and lysozyme output, the differences in salivary proteins between baseline and 3-year post-CABG were not statistically significant. No difference was observed in saliva values between patients taking drugs below or above the median number of drugs. Acidogenic microbial counts remained the same throughout the study. In conclusion, the salivary flow rates and constituents did not practically change in patients who underwent CABG surgery during the 3-year follow-up.

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Acknowledgements

JHM is supported by grant TYH 3245 by Helsinki University Central Hospital, Helsinki, Finland and Ulf Nilsonne Foundation (SalusAnsvar Prize), Stockholm, Sweden, and by the Päivikki and Sakari Sohlberg Foundation, Helsinki, Finland. SJK is funded by The National Scientist Development Grant from The American Heart Association (# 0635351N).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland

    Markku Qvarnström

  2. Department of General Dentistry, Boston University School of Dental Medicine, Boston, USA

    Sok-Ja Janket

  3. Department of Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland

    Pekka Nuutinen

  4. Institute of Dentistry, University of Helsinki, PB 41, 00014, Helsinki, Finland

    Jussi Furuholm & Jukka H. Meurman

  5. Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland

    Jukka H. Meurman

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  1. Markku Qvarnström
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  2. Sok-Ja Janket
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  3. Pekka Nuutinen
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  4. Jussi Furuholm
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  5. Jukka H. Meurman
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Correspondence to Jukka H. Meurman.

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Qvarnström, M., Janket, SJ., Nuutinen, P. et al. Salivary constituents and acidogenic microbial counts in coronary artery bypass graft patients from baseline to three-years after operation. Clin Oral Invest 11, 217–223 (2007). https://doi.org/10.1007/s00784-007-0114-3

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  • DOI: https://doi.org/10.1007/s00784-007-0114-3

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