Abstract.
To find evidence of salivary gland involvement in human type 1 diabetes, we explored the changes in aminotransferase and lactate dehydrogenase activities, as indices of cellular injury, in the whole saliva of diabetic children. Although no significant difference in these enzymatic activities was observed between control and diabetic children as a whole, a negative correlation was found between enzymatic activities and duration of the disease, the highest values being detected in the diabetic subgroup diagnosed for less than 4 years. This suggests that some cell damage could be present in salivary glands of recently diagnosed diabetic children, likely as a result of immune-mediated alterations. In conclusion, these results may support the hypothesis that, as in rodents, the salivary glands could be an additional target of the immunological attack mainly directed against pancreatic β-cells and resulting in type 1 diabetes.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Cinquini, I., Calisti, L., Fierabracci, V. et al. Enzymatic markers of salivary cell injury in saliva of type 1 diabetic children. Clin Oral Invest 6, 21–23 (2002). https://doi.org/10.1007/s00784-002-0154-7
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00784-002-0154-7