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Trans-pyridine tetraammine complexes of RuII and RuIII with N7-coordninated purine nucleosides

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Abstract

 The synthesis, spectroscopic, and electrochemical properties of trans-[L(Pyr)(NH3)4RuII/III] (Pyr=py, 3-phpy, 4-phpy, 3-bnpy, or 4-bnpy; L=H2O, Guo, dGuo, 1MeGuo, Gua, Ino, or G7-DNA) are reported. As expected, the Pyr ligand slows DNA binding by trans-[(H2O)(Pyr)(NH3)4RuII]2+ relative to [(H2O)(NH3)5RuII]2+ and favors reduction of RuIII by about 150 mV. The pyridine ligand also promotes the disproportionation of RuIII to afford the corresponding complexes of RuII and, presumably, RuIV. For L=Ino, disproportionation follows the rate law: d[RuII]/dt=k 0[RuIII]+k 1[OH–][RuIII], k 0=(2.7±0.7)×10–4 s–1 and k 1=70±1 M–1 s–1.

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Authors and Affiliations

  1. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA e-mail: clarke@bc.edu, Fax: +1-617-5522705, , , , , , US

    Ming Zhao & M. J. Clarke

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  1. Ming Zhao
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  2. M. J. Clarke
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Received: 11 May 1998 / Accepted: 3 March 1999

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Zhao, M., Clarke, M. Trans-pyridine tetraammine complexes of RuII and RuIII with N7-coordninated purine nucleosides. JBIC 4, 318–324 (1999). https://doi.org/10.1007/s007750050318

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  • DOI: https://doi.org/10.1007/s007750050318

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