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JBIC Journal of Biological Inorganic Chemistry

, Volume 2, Issue 6, pp 675–679 | Cite as

Chromium in carbohydrate and lipid metabolism

  • C. Michele Davis
  • J. B. Vincent
MINIREVIEW

Abstract

 Since the discovery in the 1950s that mammals have a nutritional requirement for chromium, the biological function of chromium has been sought. Candidates for the naturally-occurring biologically active form of chromium have been proposed, but, until recently, all have been shown to be artifacts. Recent studies examining the properties of the oligopeptide low-molecular-weight chromium-binding substance (LMWCr) suggest that this material may have a role in carbohydrate and lipid metabolism as part of a novel insulin-signaling amplification mechanism and may have implications in the treatment of diabetes and related conditions.

Key words Chromium Insulin receptor Low-molecular-weight chromium-binding substance Diabetes Glucose tolerance factor 

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Copyright information

© Society of Biological Inorganic Chemistry 1997

Authors and Affiliations

  • C. Michele Davis
    • 1
  • J. B. Vincent
    • 1
  1. 1.Department of Chemistry, University of Alabama, Tuscaloosa, AL 35487-0336, USA Tel.: +1-205-348-9203; Fax: +1-205-348-9104; e-mail: JVINCENT@ua1vm.ua.eduVC

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