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Cu-BTC metal–organic framework as a biocompatible nanoporous carrier for chlorhexidine antibacterial agent

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Abstract

Antibacterial materials are an essential part of modern life and many efforts have been made to find a new and effective type of them. In this study, chlorhexidine (CHX) was loaded on Cu-BTC metal–organic framework (MOF), that both of them are known to have antibacterial properties. The antibacterial properties of Cu-BTC, CHX and CHX@Cu-BTC were investigated against Gram-positive and Gram-negative bacteria. Agar well-diffusion method and MIC test showed that CHX@Cu-BTC has high antibacterial activity. Characterization methods, such as FT-IR, XRD, N2 adsorption–desorption isotherm, TGA, SEM, EDX, TEM and zeta potential, were employed to characterize their structures.

Graphical abstract

Cu-BTC MOF nanoparticles were synthesized and used as nanoporous carriers for chlorhexidine. The loading was about 10%, which was absorbed into the pores. Antibacterial activity was investigated against Gram-negative and Gram-positive bacteria by Agar well diffusion method and MIC (minimal inhibitory concentration) assay. The CHX@Cu-BTC had synergistic antibacterial activity of Cu-BTC and chlorhexidine.

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Acknowledgements

Support of this investigation by the Iran National Science Foundation (INSF) under grant number 9800678 is gratefully acknowledged. The authors also would like to acknowledge the financial support of the University of Tehran for this research under grant number 01/1/389845.

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  1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Sajjad Soltani & Kamran Akhbari

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  1. Sajjad Soltani
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  2. Kamran Akhbari
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Correspondence to Kamran Akhbari.

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Soltani, S., Akhbari, K. Cu-BTC metal–organic framework as a biocompatible nanoporous carrier for chlorhexidine antibacterial agent. J Biol Inorg Chem 27, 81–87 (2022). https://doi.org/10.1007/s00775-021-01912-5

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