Skip to main content
SpringerLink
Log in

In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the SMART Programme

  • Brief Report
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

This nationwide surveillance of clinically important bacteria from the intensive care units (ICUs) of major teaching hospitals throughout Taiwan investigated the susceptibilities to doripenem and other comparator carbapenems from September through November 2005. Minimum inhibitory concentrations (MICs) were determined for 1,311 clinical isolates using the broth microdilution method according to Clinical and Laboratory Standards Institute (CLSI) 2005 guidelines. Doripenem showed similar (within four-fold difference of MICs) in vitro activity to meropenem for Enterobacteriaceae and probably comparable activity to meropenem against important nosocomial non-fermentative Gram-negative bacilli (NFGNBs), including Pseudomonas aeruginosa, Acinetobacter baumannii and Burkholderia cepacia. Among the four carbapenems analysed, doripenem and meropenem exhibited better in vitro activity than imipenem or ertapenem against extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli isolates. However, the meropenem MIC90 against ESBL-producing K. pneumoniae isolates was 2 µg/ml. Besides, doripenem with the MIC90 of 0.5 µg/ml to Streptococcus pneumoniae possibly suggested its potential therapeutic effect regarding community-acquired pneumonia. Because of the heavy resistance burden in Taiwan, closely monitoring the evolutionary trend of carbapenem susceptibilities against clinically important pathogens is crucial in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Jones RN, Sader HS, Fritsche TR (2005) Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various beta-lactamase resistance mechanisms. Diagn Microbiol Infect Dis 52:71–74

    Article  CAS  PubMed  Google Scholar 

  2. Jean SS, Hsueh PR, Lee WS, Chang HT, Chou MY, Chen IS et al (2009) Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan. Eur J Clin Microbiol Infect Dis 28:215–220

    Article  CAS  PubMed  Google Scholar 

  3. Clinical and Laboratory Standards Institute (CLSI) (2005) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically—sixth edition: approved standard M7-A6. CLSI, Wayne, PA, USA

  4. Clinical and Laboratory Standards Institute (CLSI) (2005) Performance standards for antimicrobial susceptibility testing—fifteenth informational supplement: M100-S19. CLSI, Wayne, PA, USA

  5. Fritsche TR, Stilwell MG, Jones RN (2005) Antimicrobial activity of doripenem (S-4661): a global surveillance report (2003). Clin Microbiol Infect 11:974–984

    Article  CAS  PubMed  Google Scholar 

  6. Jones RN, Huynh HK, Biedenbach DJ (2004) Activities of doripenem (S-4661) against drug-resistant clinical pathogens. Antimicrob Agents Chemother 48:3136–3140

    Article  CAS  PubMed  Google Scholar 

  7. Scheetz MH, Esterly JS, Malczynski M, Postelnick M, Qi C (2009) Impact of dissimilar susceptibility breakpoints for doripenem on susceptibility and carbapenem discordance for Pseudomonas aeruginosa. Diagn Microbiol Infect Dis 64:465–467

    Article  CAS  PubMed  Google Scholar 

  8. Jean SS, Hsueh PR, Lee WS, Chang HT, Chou MY, Chen IS et al (2009) Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in intensive care units in Taiwan: SMART programme data 2005. Int J Antimicrob Agents 33:266–271

    Article  CAS  PubMed  Google Scholar 

  9. Brown SD, Traczewski MM (2005) Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: tentative disc diffusion criteria and quality control. J Antimicrob Chemother 55:944–949

    Article  CAS  PubMed  Google Scholar 

  10. Davies TA, Shang W, Bush K, Flamm RK (2008) Activity of doripenem and comparator beta-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x. J Antimicrob Chemother 61:751–753

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

No funding sources.

Competing interests

None declared.

Author information

Authors and Affiliations

  1. Departments of Intensive Care Units and Internal Medicine, Min-Sheng General Hospital, Taoyuan County, Taiwan

    S.-S. Jean

  2. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University Medical College, 7 Chung-Shan South Road, 100, Taipei, Taiwan

    P.-R. Hsueh

  3. Department of Internal Medicine, Taipei Municipal WanFang Hospital, Taipei, Taiwan

    W.-S. Lee

  4. Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan

    H.-T. Chang

  5. Department of Internal Medicine, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan

    M.-Y. Chou

  6. Department of Internal Medicine, Cardinal Tien Hospital, Taipei County, Taiwan

    I.-S. Chen

  7. Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan

    J.-H. Wang

  8. Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    C.-F. Lin

  9. Department of Clinical Pathology, Taichung Veterans General Hospital, Taichung, Taiwan

    J.-M. Shyr

  10. Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan

    W.-C. Ko

  11. School of Medical Technology, National Cheng-Kung University College of Medicine, Tainan, Taiwan

    J.-J. Wu

  12. Department of Clinical Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

    Y.-C. Liu

  13. Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

    W.-K. Huang

  14. School of Medical Technology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    L.-J. Teng

  15. Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    C.-Y. Liu

Authors
  1. S.-S. Jean
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P.-R. Hsueh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W.-S. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H.-T. Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M.-Y. Chou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I.-S. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J.-H. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C.-F. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J.-M. Shyr
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. W.-C. Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J.-J. Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Y.-C. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. W.-K. Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. L.-J. Teng
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. C.-Y. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P.-R. Hsueh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jean, SS., Hsueh, PR., Lee, WS. et al. In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the SMART Programme. Eur J Clin Microbiol Infect Dis 29, 471–475 (2010). https://doi.org/10.1007/s10096-009-0866-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-009-0866-6

Keywords

Search

Navigation