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Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

 The aim of this study is to evaluate and compare the trabecular bone scores (TBSs) of 11 children and 24 adults with X-linked hypophosphatemic rickets (XLH) and non-XLH subjects from a tertiary center.

Materials and methods

 The areal bone mineral density at the lumbar spine (LS-aBMD) and LS-aBMD Z score were analyzed by dual-energy X-ray absorptiometry. The bone mineral apparent density (BMAD) and LS-aBMD Z score adjusted for height Z score (LS-aBMD–HAZ) were calculated. The TBS was determined using TBS iNsight software based on DXA images from the Hologic QDR 4500 device.

Results

The XLH patients exhibited a higher mean LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects (p < 0.01). LS-aBMD–HAZ and BMAD were greater in the XLH children than those in their corresponding non-XLH subjects (p < 0.01 and p = 0.02), and the XLH children trended toward a greater TBS (p = 0.06). The XLH adults had a higher LS-aBMD Z score, BMAD, and TBS than the non-XLH subjects (p < 0.01). When stratified by metabolic status according to the serum values of bone formation markers, compensated adult patients had a higher LS-aBMD Z score, BMAD, and TBS than non-XLH subjects (p < 0.01). Noncompensated patients had higher LS-aBMD Z scores and BMAD results than non-XLH subjects. However, TBS values did not differ statistically significantly between those groups (p = 0.45).

Conclusion

The higher LS-aBMD Z score, BMAD, and TBS result in the XLH patients compared to non-XLH subjects indicates an increased amount of trabecular bone within the lumbar spine, regardless of extraskeletal calcifications.

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Acknowledgements

No benefits in any form have been received or will be received from a commercial party directly or indirectly related to the subject of this article.

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Authors and Affiliations

  1. Osteometabolic Disorders Unit, Endocrinology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155-PAMB, 8° Andar, Bloco 3, São Paulo, SP, CEP: 05403-900, Brazil

    Guido de Paula Colares Neto & Regina Matsunaga Martin

  2. Hormone and Molecular Genetics Laboratory (LIM/42), Endocrinology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155-PAMB, 2° Andar, Bloco 6, São Paulo, SP, CEP: 05403-900, Brazil

    Guido de Paula Colares Neto, Mariana Ferreira de Assis Funari & Regina Matsunaga Martin

  3. Bone Metabolism Laboratory (LIM/17), Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, 3º Andar, Sala 3193, São Paulo, SP, CEP: 01246-903, Brazil

    Rosa Maria Rodrigues Pereira, Jackeline Couto Alvarenga & Liliam Takayama

Authors
  1. Guido de Paula Colares Neto
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  2. Rosa Maria Rodrigues Pereira
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  3. Jackeline Couto Alvarenga
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  4. Liliam Takayama
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  5. Mariana Ferreira de Assis Funari
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  6. Regina Matsunaga Martin
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Contributions

Conceptualization and methodology: CNGP, RPRMM, and RM. Formal analysis and investigation: CNGP, AJC, TL. FMFA, and MRM. Writing: CNGP and MRM.

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Correspondence to Guido de Paula Colares Neto.

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de Paula Colares Neto, G., Pereira, R.M.R., Alvarenga, J.C. et al. Evaluation of the trabecular bone score in 35 children and adults with X-linked hypophosphatemic rickets. J Bone Miner Metab 41, 666–672 (2023). https://doi.org/10.1007/s00774-023-01442-x

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