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The potential role of lncRNAs in osteoporosis

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Osteoporosis is a common bone disease characterized by low bone mass and deterioration of bone microstructure, which predisposes to higher risks of bone fragility and bone fracture. Long non-coding RNAs (lncRNAs) are a class of RNAs with a length of > 200 nucleotides without protein-coding function, which control the expression of genes and affect multiple biological processes. Accumulating evidence suggests that lncRNAs are widely involved in the molecular mechanisms of osteoporosis. This review aims to summarize the function and underlying mechanism of lncRNAs involved in the development of osteoporosis, and how it contributes to osteoblast and osteoclast function. This knowledge will shed new light on the modulation and potential treatment of osteoporosis.

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Authors and Affiliations

  1. Department of Orthopaedic Trauma, The Third Hospital of Shijiazhuang, Shijiazhuang, 050000, Hebei, People’s Republic of China

    Yinxi He

  2. Department of Endocrinology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, 050000, Hebei, People’s Republic of China

    Yanxia Chen

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  1. Yinxi He
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He, Y., Chen, Y. The potential role of lncRNAs in osteoporosis. J Bone Miner Metab 39, 341–352 (2021). https://doi.org/10.1007/s00774-021-01205-6

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