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Bone: a key aspect to understand phenomena in clinical hematology

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Abstract

The bone marrow (BM) is located inside the bone. Now, it appears that bone tissue functionally communicates with the BM hematopoietic system. Osteoblast lineage cells serve as a part of the microenvironment for immature hematopoietic (stem/progenitor) cells. In contrast, mature hematopoietic cells such as neutrophils and macrophages play a critical role to regulate osteoblast activity. A progressive distortion of this precise inter-organ communication between hematopoietic and skeletal systems may lead to hematologic disorders. Recent studies have revealed that vitamin D receptor is a pivotal bridging molecule for this network and for the pathogenesis of myelofibrosis.

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Funding

This work was supported in part by a CREST grant from AMED (JP18gm0910012h2 to Y.K.).

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Authors and Affiliations

  1. Hematology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Kanako Wakahashi & Yoshio Katayama

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  1. Kanako Wakahashi
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  2. Yoshio Katayama
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Correspondence to Yoshio Katayama.

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Wakahashi, K., Katayama, Y. Bone: a key aspect to understand phenomena in clinical hematology. J Bone Miner Metab 38, 145–150 (2020). https://doi.org/10.1007/s00774-019-01075-z

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  • DOI: https://doi.org/10.1007/s00774-019-01075-z

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