Abstract
In clinical assays, interfering substances can cause large errors, which in turn can result in severe patient harm. Yet, perhaps because such errors are rare, not much attention is devoted to interferences. This is evident in specifications, which often focus on most, but not all of the results. Methods such as total error analysis, six sigma, and measurement uncertainty intervals are all useful but fail to properly account for interferences, and the Clinical Laboratory Standards Institute standard on interferences has misleading reporting advice. Suggestions are given to improve specifications, protocols, analyses, and reporting methods.
References
Vogeser M, Seger C (2017) Irregular analytical errors in diagnostic testing—a novel concept. Clin Chem Lab Med. https://doi.org/10.1515/cclm-2017-0454
Plebani M (2017) Analytical quality: an unfinished journey. Clin Chem Lab Med. https://doi.org/10.1515/cclm-2017-0717
Theodorsson E, Magnusson B (2017) Full method validation in clinical chemistry. Accred Qual Assur 22:235–246
EP07-A2 (2005) Interference testing in clinical chemistry, 2nd Edn. CLSI, Wayne, USA
Sandberg S, Fraser CG, Horvath AR, Jansen R, Jones G et al (2015) Defining analytical performance specifications: consensus Statement from the 1st strategic conference of the european federation of clinical chemistry and laboratory medicine. Clin Chem Lab Med 53:833–835
Parkes J, Slatin SL, Pardo S, Ginsberg BH (2000) A new consensus error grid to evaluate the clinical significance of inaccuracies in the measurement of blood glucose. Diabetes Care 23:1143–1148
Recommendations: Clinical Laboratory Improvement Amendments of 1988 (CLIA) Waiver Applications for Manufacturers of In Vitro Diagnostic Devices. https://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm070890.pdf. Accessed Oct 2017
CLIA Limits Federal Register. https://www.gpo.gov/fdsys/pkg/CFR-2016-title42-vol5/pdf/CFR-2016-title42-vol5-sec493-931.pdf. Accessed March 2018
Desirable Biological Variation Database specifications Westgard web site. https://www.westgard.com/biodatabase1.htm. Accessed March 2018
Klonoff DC, Lias C, Vigersky R et al (2014) The surveillance error grid. J Diabetes Sci Technol 8(4):658–672
ISO 15197 (2013) Glucose monitoring systems for self-testing in managing diabetes mellitus. International Organization for Standardization, Geneva, Switzerland
Boyd JC, Bruns DE (2001) Quality specifications for glucose meters: assessment by simulation modeling of errors in insulin dose. Clin Chem 47:209–214
Krouwer JS (2001) How to improve total error modeling by accounting for error sources beyond imprecision and bias. Clin Chem 47:1329–1330
Boyd JC, Bruns DE (2001) Drs. Boyd and Bruns respond. Clin Chem 47:1330–1331
Lawton WH, Sylvester EA, Young-Ferraro BJ (1979) Statistical comparison of multiple analytic procedures: application to clinical chemistry. Technometrics 21:397–409
Westgard JO and Westgard SA (2013) Total analytic error from concept to application Clinical Laboratory News. https://www.aacc.org/publications/cln/articles/2013/september/total-analytic-error. Accessed Oct 2017
Krouwer JS (2014) The danger of using total error models to compare glucose meter performance. J Diabetes Sci Technol 8:419–421
Krouwer JS (2016) The problem with total error models in establishing performance specifications and a simple remedy. Clin Chem Lab Med 54:1299–1301
Krouwer JS, Monti KL (1995) A simple graphical method to evaluate laboratory assays. Eur J Clin Chem Clin Biochem 33:525–527
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Krouwer, J.S. Interferences, a neglected error source for clinical assays. Accred Qual Assur 23, 189–192 (2018). https://doi.org/10.1007/s00769-018-1315-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00769-018-1315-y