Abstract
Certified reference materials (CRMs) are used in analytical chemistry for method validation studies in order to establish measurement accuracy, traceability, and long-term stability throughout repeated analyses. Quality control (QC) during routine analysis requires access to stable materials appropriate for the sample matrix being analyzed. However, it may be difficult to find representative, low-cost QC materials, especially for specific analytes in biological tissue matrices. Here, four caprine liver pools are prepared for use as internal QC materials for trace element measurements in biological tissue. Analytes of interest include essential and nonessential trace elements and the lanthanide series elements. The suitability of caprine liver to serve as a secondary reference material (RM), as well as for routine QC purposes, is demonstrated through homogeneity and stability measurements, and the acquisition of precision and uncertainty data. Traceability is established for selected analytes for which available CRMs can provide an unbroken chain of calibrations.
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Acknowledgments
The authors gratefully acknowledge Dr. Frank S. Blaisdell, Facility Veterinarian, for his dedication to the animals that made this study possible. We also thank Dr. Christopher D. Palmer for technical assistance, and Dr. Adriana Verschoor for manuscript editing.
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Kruger, P.C., Geraghty, C.M. & Parsons, P.J. Development of caprine liver quality control materials for trace element analysis of biological tissues. Accred Qual Assur 15, 451–458 (2010). https://doi.org/10.1007/s00769-010-0660-2
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DOI: https://doi.org/10.1007/s00769-010-0660-2