Zusammenfassung
Hintergrund
Maßnahmen außerhalb der konventionellen Medizin werden von Patienten genutzt, um die Heilungschancen zu verbessern.
Ziel
Dieser Beitrag versucht die Frage zu beantworten, ob komplementäronkologische Maßnahmen geeignet sind, eine Verbesserung der Heilungschancen bei malignen Tumorerkrankungen zu bewirken.
Material und Methoden
Es erfolgte eine umfangreiche Literaturrecherche.
Ergebnisse
Es besteht die Möglichkeit, dass es durch 1. verschiedene Ansätze möglich ist, die Verträglichkeit der Behandlung zu verbessern, wodurch sich seltener Therapieabbrüche und/oder eine höhere Dosisintensität ergibt, was nachweislich mit einer besseren Prognose einhergeht, 2. komplementäre Methoden die Wirksamkeit der Methoden der klassischer Medizin erhöhen können und 3. sich komplementäre Methoden zur Verhinderung des Rezidivs eignen können, nachdem die klassische Therapie beendet ist.
Schlussfolgerung
Voraussetzung für eine Verbesserung der Prognose scheinen rational begründbare Ansätze zu sein, die die Situation des Patienten, die Tumorentität und die Therapie berücksichtigen. Es finden sich keine Hinweise dafür, dass beliebige, irrationale oder esoterische Therapiekonzepte ebenfalls zu einer Prognoseverbesserung beitragen könnten.
Abstract
Background
Methods outside the field of conventional medicine are frequently used by cancer patients to improve the chance of finding a cure.
Aim
This article attempts to answer the question whether methods from complementary medicine can improve the prognosis of patients with malignant diseases.
Material and methods
A comprehensive literature search was carried out.
Results
It has been shown that there is a chance for improvement in the tolerance of treatment because 1) various methods can reduce the side effects of conventional forms of treatment, which leads to better adherence to classical treatment approaches and higher dose densities. Both have been shown to lead to a better prognosis; 2) methods from complementary medicine can improve the efficacy of methods from conventional medicine and 3) methods from complementary medicine can reduce the likelihood of a recurrence after termination of classical treatment.
Conclusion
A rational approach to complementary medicine is a prerequisite for improving the prognosis. The patient situation, tumor entity and current treatment must be considered when a method from complementary medicine is selected on the basis of evidence-based medicine. There is no evidence that arbitrary, irrational or esoteric concepts also contribute to improvement of the prognosis.
Literatur
Adisa AO, Lawal OO, Adesunkanmi AR (2008) Paradox of wellness and nonadherence among Nigerian women on breast cancer chemotherapy. J Cancer Res Ther 4:107–110
Bittenbring JT, Neumann F, Altmann B, Achenbach M, Reichrath J, Ziepert M, Geisel J, Regitz E, Held G, Pfreundschuh M (2014) Vitamin d deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B‑cell lymphoma treated with but not without rituximab. J Clin Oncol 32:3242–3248
Chi F, Wu R, Zeng YC, Xing R, Liu Y, Xu ZG (2013) Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pac J Cancer Prev 14:2407–2412
Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH (2015) Effects of honey on oral mucositis in patients with head and neck cancer: a meta-analysis. Laryngoscope 125:2085–2092
Fink M (2011) Vitamin D deficiency is a cofactor of chemotherapy-induced mucocutaneous toxicity and dysgeusia. J Clin Oncol 29:e81–e82
Goodwin PJ, Ennis M, Pritchard KI, Koo J, Trudeau ME, Hood N (2003) Diet and breast cancer: evidence that extremes in diet are associated with poor survival. J Clin Oncol 21:2500–2507
Hershman DL, Kushi LH, Shao T, Buono D, Kershenbaum A, Tsai WY, Fehrenbacher L, Gomez SL, Miles S, Neugut AI (2010) Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol 28:4120–4128
Khan M, Maryam A, Mehmood T, Zhang Y, Ma T (2015) Enhancing activity of anticancer drugs in multidrug resistant tumors by modulating p‑glycoprotein through dietary nutraceuticals. Asian Pac J Cancer Prev 16:6831–6839
Li Z, Carrier L, Rowan BG (2008) Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells. Mol Cancer Ther 7:3056–3063
Ling WM, Lui LY, So WK, Chan K (2014) Effects of acupuncture and acupressure on cancer-related fatigue: a systematic review. Oncol Nurs Forum 41:581–592
Meneses-Echávez JF, González-Jiménez E, Ramírez-Vélez R (2015) Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis. BMC Cancer 15:77
Oberoi S, Zamperlini-Netto G, Beyene J, Treister NS, Sung L (2014) Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis. PLOS ONE 9:e107418
Ogunleye AA, Xue F, Michels KB (2010) Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 119:477–484
Qi Y, Fu X, Xiong Z, Zhang H, Hill SM, Rowan BG, Dong Y (2012) Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer. PLOS ONE 7:e31539
Riley P, Glenny AM, Worthington HV, Littlewood A, Clarkson JE, McCabe MG (2015) Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy. Cochrane Database Syst Rev 12:CD011552
Song HJ, Seo HJ, Lee H, Son H, Choi SM, Lee S (2015) Effect of self-acupressure for symptom management: a systematic review. Complement Ther Med 23:68–78
Tang WR, Chen WJ, Yu CT, Chang YC, Chen CM, Wang CH, Yang SH (2014) Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med 22:581–591
Trudel D, Labbé DP, Araya-Farias M, Doyen A, Bazinet L, Duchesne T, Plante M, Grégoire J, Renaud MC, Bachvarov D, Têtu B, Bairati I (2013) A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer. Gynecol Oncol 131:357–361
Vadgama JV, Wu Y, Shen D, Hsia S, Block J (2000) Effect of selenium in combination with Adriamycin or Taxol on several different cancer cells. Anticancer Res 20:1391–1414
Van Liew JR, Christensen AJ, de Moor JS (2014) Psychosocial factors in adjuvant hormone therapy for breast cancer: an emerging context for adherence research. J Cancer Surviv 8:521–531
Wang L, Gu Z, Zhai R, Zhao S, Luo L, Li D, Zhao X, Wei H, Pang Z, Wang L, Liu D, Wang Q, Gao C (2015) Efficacy of oral cryotherapy on oral mucositis prevention in patients with hematological malignancies undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials. PLOS ONE 10:e0128763
Zeichner SB, Koru-Sengul T, Shah N, Liu Q, Markward NJ, Montero AJ, Glück S, Silva O, Ahn ER (2014) Improved clinical outcomes associated with vitamin D supplementation during adjuvant chemotherapy in patients with HER2+ nonmetastatic breast cancer. Clin Breast Cancer 15:e1–e11
Zhong S, Jiang T, Ma T, Zhang X, Tang J, Chen W, Lv M, Zhao J (2014) Association between physical activity and mortality in breast cancer: a meta-analysis of cohort studies. Eur J Epidemiol 29:391–404
Zick SM, Sen A, Wyatt GK, Murphy SL, Arnedt JT, Harris RE (2016) Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: a randomized clinical trial. JAMA Oncol. doi:10.1001/jamaoncol.2016.1867
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K. Münstedt, W. Gießler und T. Schopperth geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
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Münstedt, K., Gießler, W. & Schopperth, T. Komplementäre Onkologie und Prognose. Onkologe 23, 185–189 (2017). https://doi.org/10.1007/s00761-016-0155-9
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DOI: https://doi.org/10.1007/s00761-016-0155-9