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Role of VEGF in an experimental model of cortical micronecrosis

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Summary.

 Vascular endothelial growth factor (VEGF) is a major mediator in angiogenesis and vascular permeability. In central nervous system (CNS) it plays a pivotal role as: 1. inductor of endothelial cell proliferation, migration and inhibition of apoptosis, and 2. mediator of vascular permeability and subsequently of brain edema. This ubiquitous epiphenomenon is a major complication in several CNS pathologies, including head trauma and stroke.

After brain injury the expression of VEGF is increased contributing to disruption of the blood brain barrier (BBB). VEGF increase the permeability of BBB via the synthesis/release of nitric oxide and subsequent activation of soluble guanylate cyclase. The immunohistochemistry shows an increase of stained astrocytes and endothelial cells around cortical micronecrosis. VEGF immunopositivity distribution shows some correspondence with the blood brain barrier breakdown following a cortical micronecrosis.

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Authors and Affiliations

  1.  Department of Neurosciences, University of Basque Country, Leioa, Spain, , , , , , ES

    J. V. Lafuente, S. Bulnes & B. Mitre

  2.  Department of Immunology & Oncology, Centro Nacional de Biotecnología, C.S.I.C./U.A.M., Madrid, Spain, , , , , , ES

    H. H. Riese

Authors
  1. J. V. Lafuente
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  2. S. Bulnes
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  3. B. Mitre
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  4. H. H. Riese
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Received July 3, 2001 Accepted August 6, 2001 Published online September 10, 2002

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Lafuente, J., Bulnes, S., Mitre, B. et al. Role of VEGF in an experimental model of cortical micronecrosis. Amino Acids 23, 241–245 (2002). https://doi.org/10.1007/s00726-001-0135-1

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  • DOI: https://doi.org/10.1007/s00726-001-0135-1

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