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Dynamic Viscosity of Blood Serum Determined Using Proton Magnetic Relaxation

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Abstract

An experimental procedure, based on proton magnetic relaxation, is presented to determine the absolute dynamic viscosity in blood serum (ηS). The blood serum samples were obtained voluntary from whole blood of healthy individuals and patients, and processed by classical methods (centrifugation and decanting). The Carr–Purcell–Meiboom–Gill pulse sequence was employed to determine the transverse proton magnetic relaxation time (T2) in a Tecmag Magnetic Resonance console coupled to a magnet of 0.095 T and the temperature of measurement was 293 K. A theoretical linear behavior of the transverse proton magnetic relaxation rate (1/T2) as a function of ηS was obtained after the consideration of blood serum as an extremely diluted solution of albumin and globulins, and assuming a fast exchange of water molecules between the bound phase and the solvent. A value of ηS = 1.29 ± 0.07 mPa s was obtained in samples belonging to 20 voluntary healthy individuals, which statistically match with the value obtained using the Ostwald viscometer for the same samples (ηS = 1.32 ± 0.04 mPa s, P = 0.104319 > 0.05, α = 0.05). The potential medical utility of the presented proton magnetic resonance procedure was demonstrated in patients with Multiple Myeloma (24) and Sickle Cell Disease (34), in which ηS resulted increased with values of 1.40 ± 0.18 mPa s (P = 0.0137509 < 0.05, α = 0.05) and 1.36 ± 0.10 mPa s (P = 0.00809615 < 0.05, α = 0.05), respectively.

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Acknowledgements

This work has been supported by the Belgian Development Cooperation through VLIR-UOS (Flemish Interuniversity Council-University Cooperation for Development) in the context of the Institutional University Cooperation program with Universidad de Oriente. The authors also want to thank the MRI RESEARCH CENTRE of the University of New Brunswick, Fredericton, Canada, for all the support received to finalize this work.

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Author notes

  1. Yulianela Mengana Torres and Manuel Arsenio Lores Guevara have the same contribution to the paper.

Authors and Affiliations

  1. Centro de Biofísica Médica, Universidad de Oriente, Patricio Lumumba S/N, CP 90500, Santiago de Cuba, Cuba

    Yulianela Mengana Torres, Manuel Arsenio Lores Guevara, Juan Carlos García Naranjo & Yamirka Alonso Geli

  2. Departamento de Física, Facultad de Ciencias Naturales y Exactas, Universidad de Oriente, Patricio Lumumba S/N, CP 90500, Santiago de Cuba, Cuba

    Hugo Ferrales Milán

  3. Hospital General Docente “Dr. Juan Bruno Zayas Alfonso”, Carretera del Caney, Esquina 23, Reparto Pastorita, Santiago de Cuba, Cuba

    Lidia Clara Suárez Beyries, Samuel Jorge Rosales Rodríguez & Inocente Rodríguez Reyes

Authors
  1. Yulianela Mengana Torres
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  2. Manuel Arsenio Lores Guevara
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  8. Yamirka Alonso Geli
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Contributions

Conceptualization: Yulianela Mengana Torres, Manuel Arsenio Lores Guevara; methodology: Yulianela Mengana Torres, Manuel Arsenio Lores Guevara, Hugo Ferrales Milán, formal analysis and investigation: Yulianela Mengana Torres, Manuel Arsenio Lores Guevara, Hugo Ferrales Milán, Yamirka Alonso Geli; writing—original draft preparation: Manuel Arsenio Lores Guevara; writing—review and editing: Yulianela Mengana Torres, Manuel Arsenio Lores Guevara, Juan Carlos García Naranjo; resources: Lidia Clara Suárez Beyries, Samuel Jorge Rosales Rodríguez, Inocente Rodríguez Reyes; supervision: Yulianela Mengana Torres, Manuel Arsenio Lores Guevara, Juan Carlos García Naranjo.

Corresponding author

Correspondence to Manuel Arsenio Lores Guevara.

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Ethical approval

This research has been performed in agreement with all the ethical rules corresponding to scientific research in human beings in accordance with the provisions of the Declaration of Helsinki (1964, updated until 2013) of the World Medical Association. The approval from the ethical committee of the “Juan Bruno Zayas Alfonso” General Hospital was obtained.

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The authors declare no competing financial and/or non-financial interest.

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Mengana Torres, Y., Lores Guevara, M.A., Ferrales Milán, H. et al. Dynamic Viscosity of Blood Serum Determined Using Proton Magnetic Relaxation. Appl Magn Reson (2024). https://doi.org/10.1007/s00723-024-01644-0

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  • DOI: https://doi.org/10.1007/s00723-024-01644-0

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