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Multinuclear MRI and MRS at 0.5 Tesla

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Abstract

This retrospective review presents the results of detecting MR signals (NMR spectra, NQR, and MR images) obtained on a clinical 0.5T MR scanner from nuclei other than protons (1H), namely isotopes 2H, 11B, 13C, 14N, 17O, 19F, 23Na, 35Cl, 29Si, and 31P. Also, we report here our latest developments in the field of 19F and 23Na MRI for medical, biological, and technological applications. The results were obtained without significant technical modifications of the MR scanner, with the addition of in-house built coils being the only change. Therefore, special attention in the article is paid to the technical aspects of the study. In this regard, we note the possibility to increase the effectiveness of multinuclear applications by adjusting frequency settings of the transceiver path, as in a typical clinical scanner they are optimized for the detection of only proton signals. The results of this work can be beneficial for the practical implementation of multinuclear applications at low field, have methodological value, and serve as a guidance (starting point) for research carried out on more advanced high-field equipment.

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Data availability

The authors confirm that the datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

The work was performed with the support of the Interdisciplinary Scientific and Educational Schools of Moscow University «Molecular Technologies of the Living Systems and Synthetic Biology» and «Photonic and quantum technologies. Digital medicine».

Funding

Pulmonary 19F MRI studies have been supported by Russian Science Foundation grant No. 21-75-10038. 23Na MRI studies have been supported by Russian Foundation for Basic Research grant No. 19-29-10015.

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Authors and Affiliations

  1. Faculty of Fundamental Medicine, Lomonosov Moscow State University, 119991, Moscow, Russia

    Nikolay V. Anisimov, Olga S. Pavlova & Mikhail V. Gulyaev

  2. Faculty of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia

    Olga S. Pavlova, Arina A. Tarasova, Ivan A. Usanov & Yury A. Pirogov

Authors
  1. Nikolay V. Anisimov
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  2. Olga S. Pavlova
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  3. Arina A. Tarasova
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  4. Ivan A. Usanov
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  5. Mikhail V. Gulyaev
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  6. Yury A. Pirogov
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Contributions

NVA and YAP wrote the main manuscript text; OSP and MVG prepared Fig. 2; AAT and IAU prepared Fig. 4. All authors reviewed the manuscript.

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Correspondence to Nikolay V. Anisimov.

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Anisimov, N.V., Pavlova, O.S., Tarasova, A.A. et al. Multinuclear MRI and MRS at 0.5 Tesla. Appl Magn Reson 53, 1575–1585 (2022). https://doi.org/10.1007/s00723-022-01489-5

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