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1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

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Abstract

The aquation of carboplatin, a second-generation Pt(II)-based antitumor drug, in two biologically relevant media (PBS buffer solution and RPMI-1640 medium for cell growth) has been studied by means of 1H nuclear magnetic resonance spectroscopy. The effect of the macrocyclic cavitand cucurbit[7]uril on the carboplatin aquation rates in these two types of media has also been studied. Although, the cucurbit[7]uril does not form stable inclusion complex with carboplatin, it greatly affects the carboplatin aquation rates, presumably, through the two mechanisms: prevention of the carboplatin dimer formation and encapsulation of some components of the medium.

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Acknowledgements

The work was supported by the Russian Foundation for Basic Research (RFBR) grant 18-315-00158 mol_a.

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Lavrentiev Avenue, Novosibirsk, 630090, Russia

    Irina Valerievna Mirzaeva, Irina Valentinovna Andrienko & Ekaterina Aleksandrovna Kovalenko

  2. Novosibirsk State University, 2 Pirogova Street, Novosibirsk, 630090, Russia

    Irina Valerievna Mirzaeva

  3. Research Institute of Fundamental and Clinical Immunology, 14 Yadrintsevskaya Street, Novosibirsk, 630099, Russia

    Ekaterina Aleksandrovna Pashkina

  4. Novosibirsk State Medical University, 52 Krasny Prospect, Novosibirsk, 630091, Russia

    Ekaterina Aleksandrovna Pashkina & Alina Aleksandrovna Aktanova

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  1. Irina Valerievna Mirzaeva
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  2. Irina Valentinovna Andrienko
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  3. Ekaterina Aleksandrovna Kovalenko
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Correspondence to Irina Valerievna Mirzaeva.

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Mirzaeva, I.V., Andrienko, I.V., Kovalenko, E.A. et al. 1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media. Appl Magn Reson 50, 1267–1276 (2019). https://doi.org/10.1007/s00723-019-01147-3

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  • DOI: https://doi.org/10.1007/s00723-019-01147-3

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