Summary
BACKGROUND: The first trials with the sensory contact lens Triggerfish checking the safety and tolerability in human eyes were satisfactory. This specific contact lens measures the changes of the peripheral corneal curvature due to changes of the intraocular pressure within 24 hours continuously and wirelessly. The aims of our study were (1) to perform these measurements in enucleated human eyes with stepwise change of the intraocular pressure and (2) in a healthy human eye when changing the body positions. MATERIAL AND METHODS: (1) After canulation of the enucleated human eye and after the placement of the Triggerfish contact lens the intraocular pressure was increased stepwise and monitored as well as the data from the contact lens. (2) After a period of adaption of the Triggerfish contact lens in a vertical body position the body was brought in a supine and head-down position. At any time of change of the position the intraocular pressure of the second eye was checked by a handhold applanation tonometer. RESULTS: (1) The Triggerfish did not reveal correlating results to the stepwise increase of the intraocular pressure in an enucleated human eye. (2) The Triggerfish did not reveal corresponding results to the intraocular pressure values measured by applanation tonometer of the second eye after changing body positions, even not when the experiment was repeated. CONCLUSIONS: Despite perfect laboratory conditions reproducible measurements of changes of the corneal curvature induced by changes of the intraocular pressure could not be obtained. Changes of body/head positions would expect to produce changes in the intraocular pressure and therefore changes in the profile of the Triggerfish, but these anticipated changes did not correspond to the values gained by applanation tonometry. The reasons why are yet to be examined to judge the Triggerfish reliably.
Zusammenfassung
HINTERGRUND: Die ersten Anwendungen der Sensorkontaktlinse Triggerfish waren betreffend Sicherheit und Verträglichkeit gut. Diese spezielle Kontaktlinse misst 24 Stunden kontinuierlich und kabellos die Veränderungen der Hornhautkrümmung, die durch Schwankungen des Augeninnendruckes entstehen. Ziele unsere Studie waren (1) Messungen am enukleierten Menschenauge, bei denen der Augendruck stufenweise erhöht wurde und (2) Messungen bei Lageänderungen des Körpers/Kopfes. MATERIAL UND METHODE: (1) Nach Kanülierung des enukleierten Menschenauges und Anpassung der Sensorkontaktlinse wurde der Augendruck stufenweise erhöht und die Signale von der Kontaktlinse gemessen. (2) Nach Einsetzen der Sensorkontaktlinse wurde das Messprofil aufgezeichnet und beim Partnerauge in vertikaler, horizontaler und Kopf-nach-unten-Position der Augendruck applanatorisch gemessen. RESULTATE: (1) Mit der Triggerfish-Kontaktlinse ließen sich keine korrespondierenden Messprofile entsprechend den Drucksteigerungen ableiten. (2) Auch bei Lageänderungen, die zu Änderungen des applanatorisch gemessenen Augendruckes führten, fanden sich – auch bei Wiederholung des Versuches – keine entsprechenden Triggerfish-Profile. SCHLUSSFOLGERUNG: Trotz perfekter Laborbedingungen konnten keine entsprechenden Triggerfish-Profile bei schrittweiser Druckerhöhung am Leichenauge bzw. bei Lageveränderungen des menschlichen Auges abgeleitet werden. Warum dies so war sollte Ziel weiterer Untersuchungen sein, um ein seriöses Urteil über den Triggerfish abgeben zu können.
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Faschinger, C., Mossböck, G., Strohmaier, C. et al. 24-Stunden-"Augendruck" Aufzeichnung mit Sensorkontaktlinse Triggerfish: von Euphorie zur Ernüchterung. Spektrum Augenheilkd. 25, 262–268 (2011). https://doi.org/10.1007/s00717-011-0023-3
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DOI: https://doi.org/10.1007/s00717-011-0023-3