Summary.
Protonation of the reactive intermediate produced in the reaction between pyridine and dialkyl acetylenedicarboxylates by strong CH-acids such as N,N′-dimethylbarbituric acid, Meldrum’s acid, or indane-1,3-dione leads to a vinylpyridinium cation which undergoes an addition reaction with the enolate anion of the CH-acid to produce stable 1,4-diionic pyridinium betaines in good yields.
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Received February 5, 2002. Accepted (revised) March 12, 2002
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Yavari, I., Anary-Abbasinejad, M. & Alizadeh, A. A Simple Synthesis of Stable 1,4-Diionic Pyridinium Betaines. Monatshefte für Chemie 133, 1331–1336 (2002). https://doi.org/10.1007/s007060200110
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DOI: https://doi.org/10.1007/s007060200110