Summary.
The work presented in this paper deals with the combination of capillary electrophoresis (CE) with electrospray mass spectrometry (MS) for the determination of drug residues in water. CE/MS methods have been developed based on either aqueous or non-aqueous ammonium acetate solutions as the carrier electrolyte for the separation of selected drugs. The different separation conditions were compared in terms of selectivity and detection limits; both aqueous and non-aqueous CE proved to be suitable for the present analytical task, exhibiting detection limits between 3 and 93 μg/dm3 (injected standard concentration) corresponding to concentrations between 5 and 19 ng/dm3 in the sample.
A combination of liquid-liquid extraction and solid-phase extraction was investigated for sample pretreatment, yielding enrichment factors of 10000. The applicability of CE/MS was demonstrated for the analysis of several river water samples.
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Received August 25, 2000. Accepted October 17, 2000
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Ahrer, W., Buchberger, W. Combination of Aqueous and Non-Aqueous Capillary Electrophoresis with Electrospray Mass Spectrometry for the Determination of Drug Residues in Water. Monatshefte fuer Chemie 132, 329–337 (2001). https://doi.org/10.1007/s007060170119
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DOI: https://doi.org/10.1007/s007060170119