Summary.
The reaction of 4-amino-2,5-dihydro-2- and -5-methyl-3-thiophenecarbonitriles with α-diazocarbonyl compounds in the presence of rhodium(II) acetate gave regioselectively 4-cyano-2H-thiopyrans (C2-S insertion) in moderate to good yields; 5-cyano-2H-thiopyrans (C5-S insertion) were not isolated. The starting compounds were synthesized by reaction of tetrahydro-2- and -5-methyl-4-oxo-3-thiophenecarbonitriles with morpholine, piperidine, and pyrrolidine in the presence of formic acid in ethanol.
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Received November 13, 2000. Accepted December 12, 2000
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Yamagata, K., Okabe, F. & Yamazaki, M. Synthesis of 2H-Thiopyrans by Rhodium(II) Acetate-Catalyzed Reaction of 4-Amino-2,5-dihydro-3-thiophenecarbonitriles with a-Diazocarbonyl Compounds II [1]. Monatshefte fuer Chemie 132, 721–729 (2001). https://doi.org/10.1007/s007060170087
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DOI: https://doi.org/10.1007/s007060170087