Abstract
The focus has recently switched to enhancing the safety and sustainability of chemical processes in basic and applied research, pharmaceutical manufacture, and industrial chemical manufacturing. Flow chemistry approaches have attracted a lot of attention as a way to adopt and develop chemical processes to meet the increasing demand for chemical sustainability. Emerging flow chemistry methods are discussed in this mini-review, with applications in environmentally friendly high-value chemical manufacturing and efficient screening of chemical reaction space. The demand for further research and collaboration between chemists and chemical engineers in academia and business is growing as continuous production processes are increasingly being used to reduce material and energy waste. An industrial perspective on present issues is offered to spark interest and urge greater investment in greener advanced synthetic technologies.
Graphical abstract
Similar content being viewed by others
Data availability
Not applicable.
References
Guidi M, Seeberger PH, Gilmore K (2020) Chem Soc Rev 49:8910
Jensen KF (2017) AIChE J 63:858
Fitzpatrick DE, Battilocchio C, Ley SV (2016) ACS Cent Sci 2:131
Gérardy R, Emmanuel N, Toupy T, Kassin VE, Tshibalonza NN, Schmitz M, Monbaliu JCM (2018) Eur J Org Chem 2018:2301
Anastas PT, Warner JC (1998) Green chemistry: theory and practice. Oxford University Press, Oxford
Qader SA, Hill GR (1969) Ind Eng Chem Process Des Dev 8:98
Perera D, Tucker JW, Brahmbhatt S, Helal CJ, Chong A, Farrell W, Richardson P, Sach NW (2018) Science 359:429
May SA (2017) J Flow Chem 7:137
Baumann M, Moody TS, Smyth M, Wharry S (2020) Org Process Res Dev 24:1802
Battilocchio C, Bosica F, Rowe SM, Abreu BL, Godineau E, Lehmann M, Ley SV (2017) Org Process Res Dev 21:1588
Malet-Sanz L, Susanne F (2012) J Med Chem 55:4062
Gioiello A, Piccinno A, Lozza AM, Cerra B (2020) J Med Chem 63:6624
Morin MA, Zhang W, Mallik D, Organ MG (2021) Angew Chem 133:20774
Baumann M (2018) Org Biomol Chem 16:5946
Reizman BJ, Jensen KF (2016) Acc Chem Res 49:1786
Haven JJ, Junkers T (2017) Eur J Med Chem 2017:6474
Ley SV (2012) Chem Rec 12:378
Williams JD, Kappe CO (2020) Curr Opin Green Sustainable Chem 25:100351
Rogers L, Jensen KF (2019) Green Chem 21:3481
Newman SG, Jensen KF (2013) Green Chem 15:1456
Inamuddin BR, Asiri AM (2020) Sustainable organic synthesis. Elsevier, Amsterdam
Alfano AI, Brindisi M, Lange H (2021) Green Chem 23:2233
Vaccaro L, Lanari D, Marrocchi A, Strappaveccia G (2014) Green Chem 16:3680
Su Y, Kuijpers K, Hessel V, Noël T (2016) React Chem Eng 1:73
Yap SK, Wong WK, Ng NXY, Khan SA (2017) Chem Eng Sci 169:117
Zhao F, Cambié D, Janse J, Wieland WE, Kuijpers KPL, Hessel V, Debije MG, Noel T (2018) ACS Sustain Chem Eng 6:422
Ciamician G (1912) Science 36:385
Romero NA, Nicewicz DA (2016) Chem Rev 116:10075
Shaw MH, Twilton J, MacMillan DWC (2016) J Org Chem 81:6898
Liu J, Lu L, Wood D, Lin S (2020) ACS Cent Sci 6:1317
Sambiagio C, Noël T (2020) Trends Chem 2:92
Di Filippo M, Bracken C, Baumann M (2020) Molecules 25:356
Rehm TH (2020) Chem Eur J 26:16952
Kingston C, Palkowitz MD, Takahira Y, Vantouout JC, Peters BK, Kawamata Y, Baran PS (2020) Acc Chem Res 53:72
Noël T, Cao Y, Laudadio G (2019) Acc Chem Res 52:2858
Tanbouza N, Ollevier T, Lam K (2020) iScience 23:101720
Mallia CJ, Baxendale IR (2016) Org Process Res Dev 20:327
Brzozowski M, O’Brien M, Ley SV, Polyzos A (2015) Acc Chem Res 48:349
Hone CA, Kappe CO (2020) Chem Eur J 26:13108
Pye SJ, Dalgarno SJ, Chalker JM, Raston CL (2018) Green Chem 20:118
Britton J, Raston CL (2017) Chem Soc Rev 46:1250
Jiao J, Nie W, Yu T, Yang F, Zhang Q, Aihemaiti F, Yang T, Liu X, Wang J, Li P (2021) Chem Eur J 27:202
Wong SY, Chen J, Forte LE, Myerson AS (2013) Org Process Res Dev 17:684
Isbrandt ES, Sullivan RJ, Newman SG (2019) Angew Chem Int Ed 58:7180
Hwang YJ, Coley CW, Abolhasani M, Marzinzik Al, Koch G, Spanka C, Lehmann H, Jensen KF (2017) Chem Commun 53:6649
Hsieh HW, Coley CW, Baumgartner LM, Jensen KF, Robinson RI (2018) Org Process Res Dev 22:542
Escribà-Gelonch M, Noël T, Hessel V (2018) Org Process Res Dev 22:147
Coley CW, Abolhasani M, Lin H, Jensen KF (2017) Angew Chem 129:9979
Lebel H, Piras H, Borduy M (2016) ACS Catal 6:1109
Laudadio G, Barmpoutsis E, Schotten C, Struik L, Govaerts S, Browne DL, Noel T (2019) J Am Chem Soc 141:5664
Zhu C, Raghuvanshi K, Coley CW, Mason D, Rodgers J, Janka ME, Abolhasani M (2018) Chem Commun 54:8567
Fabry DC, Sugiono E, Rueping M (2016) React Chem Eng 1:129
Bana P, Szigetvari A, Koti J, Eles J, Greiner I (2019) React Chem Eng 4:652
Mullard A (2015) Nat Rev Drug Discov 14:669
Sheldon RA (2018) ACS Sustain Chem Eng 6:32
Sheldon RA (2007) Green Chem 9:1273
Sheldon RA (2017) Green Chem 19:18
Lapkin AA (eds) (2018) Green Chemical Engineering. Handbook of Green Chemistry, vol 12. Wiley-VCH Verlag GmbH, Weinheim
Amini-Rentsch L, Vanoli E, Richard-Bildstein S, Marti R, Vilé G (2019) Ind Eng Chem Res 58:10164
Das P, Delost MD, Qureshi MH, Smith DT, Njardarson JT (2019) J Med Chem 62:4265
Taylor RD, MacCoss M, Lawson ADG (2014) J Med Chem 57:5845
Larock RC, Babu S (1987) Tetrahedron Lett 28:5291
Lestari G, Abolhasani M, Bennett D, Chase P, Günther A, Kumacheva E (2014) J Am Chem Soc 136:11972
Cicci A, Sed G, Jessop PG, Bravi M (2018) Green Chem 20:3908
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Chada, S., Singh, K., Tandon, N. et al. Evaluating the green credentials of flow chemistry towards industrial applications. Monatsh Chem 154, 1205–1212 (2023). https://doi.org/10.1007/s00706-023-03130-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00706-023-03130-y