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Dendritic Cu(OH)2 nanostructures decorated pencil graphite electrode as a highly sensitive and selective impedimetric non-enzymatic glucose sensor in real human serum blood samples

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Abstract

In this study, an effective and low price non-enzymatic electrochemical glucose sensor was easily elaborated through electrodeposition of highly uniform copper dendrites hydroxide onto pencil graphite electrode (Cu(OH)2/PGE). The obtained electrode was investigated by field-emission scanning electron microscopy, atomic force microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and FT-IR characterizations. The electrocatalytic properties of the modified electrode were investigated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy techniques, which can be readily applied to determine glucose using the fabricated sensor, as the results after optimization revealed. Furthermore, a single frequency impedance method was applied for glucose determination as an alternative to conventional EIS methods. The fabricated Cu(OH)2/PGE electrode exhibited a selective impedimetric response towards glucose over an exceptional linear range from 0.1 to 12 mM (R2 = 0.999) with a detection limit of 71.8 µM. Finally, Cu(OH)2/PGE was successfully applied to the assay of glucose in blood samples with unknown interferences.

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Acknowledgements

We are very grateful to the financial support within the General Direction of Scientific Research and Technology Development of the Algerian ministry of higher education and scientific research.

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Authors and Affiliations

  1. Laboratoire d’Analyses Industrielles et Génie des Matériaux, Département de Génie des Procédés, Université 8 Mai 1945 Guelma, BP 401, 24000, Guelma, Algeria

    Chahira Boukharouba, Mouna Nacef, Mohamed Lyamine Chelaghmia, Rafiaa Kihal, Widad Drissi & Abed Mohamed Affoune

  2. Laboratoire de Chimie Appliquée, Département des Sciences de la Matière, Université 8 Mai 1945 Guelma, BP 401, 24000, Guelma, Algeria

    Hassina Fisli

  3. Groupe Analyses et Procédés (GA&P), Faculty of Sciences, University of Angers, 2 Bd. Lavoisier, 49045, Angers Cedex 01, France

    Maxime Pontié

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  1. Chahira Boukharouba
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  2. Mouna Nacef
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  3. Mohamed Lyamine Chelaghmia
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Correspondence to Mohamed Lyamine Chelaghmia.

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Boukharouba, C., Nacef, M., Chelaghmia, M.L. et al. Dendritic Cu(OH)2 nanostructures decorated pencil graphite electrode as a highly sensitive and selective impedimetric non-enzymatic glucose sensor in real human serum blood samples. Monatsh Chem 153, 171–181 (2022). https://doi.org/10.1007/s00706-021-02883-8

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