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H3PMo7W5O40·24H2O catalyzed access to fused pyrazolopyranopyrimidine derivatives via one-pot multicomponent synthesis: green chemistry

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Abstract

An economic, sustainable, and straightforward environmentally friendly route for synthesis of 3-methyl-4-aryl-1,4-dihydropyrazolo[4ʹ,3ʹ:5,6]pyrano[2,3-d]pyrimidine-5,7(6H,8H)-diones via condensation of ethyl acetoacetate, hydrazine hydrate, barbituric acid, and aromatic aldehydes in the presence of catalytic amount of H3PMo7W5O40·24H2O under solvent-free condition was reported. This environmentally benign protocol offers selective synthesis of pyrazolopyranopyrimidine derivatives without any side product with excellent yield in shorter time.

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Acknowledgements

The author DSA acknowledges UGC, New Delhi (India) for awarded senior research fellowship (SRF). The author SGS acknowledges for financial assistance under minor research project, sanction number STAT/VI/RG/DEPT/2019-20/337-38 from Dr. B. A. Marathwada University, Aurangabad (MS), India.

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Authors and Affiliations

  1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India

    Dipak S. Aher, Kiran R. Khillare & Sunil G. Shankarwar

  2. Jawaharlal Nehru Engineering College, Aurangabad, 431003, Maharashtra, India

    Laxmikant D. Chavan

Authors
  1. Dipak S. Aher
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  2. Kiran R. Khillare
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  3. Laxmikant D. Chavan
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  4. Sunil G. Shankarwar
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Correspondence to Sunil G. Shankarwar.

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Aher, D.S., Khillare, K.R., Chavan, L.D. et al. H3PMo7W5O40·24H2O catalyzed access to fused pyrazolopyranopyrimidine derivatives via one-pot multicomponent synthesis: green chemistry. Monatsh Chem 153, 79–85 (2022). https://doi.org/10.1007/s00706-021-02868-7

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  • DOI: https://doi.org/10.1007/s00706-021-02868-7

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