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Ascorbic acid: an efficient organocatalyst for environmentally benign synthesis of indole-substituted 4H‑chromenes

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Abstract

An expedient, straightforward, and efficient one-pot three-component synthesis of biologically relevant indole-substituted 4H-chromenes has been developed by the reaction of various indoles, malononitrile, and salicylaldehydes using a catalytic amount of ascorbic acid in aqueous ethanol at room temperature. The significant features of the developed protocol are the clean reaction profile, operational simplicity, non-hazardous experimental conditions, no column chromatographic purification, use of an inexpensive, commercially available, and non-toxic metal-free catalyst, accomplishment of good to excellent yields, and large-scale synthesis.

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Acknowledgements

D.D. acknowledges the financial support (project ref. No YSS/2015/001425) from Science & Engineering Research Board (SERB), New Delhi.

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  1. Department of Chemistry, Triveni Devi Bhalotia College, Raniganj, India

    Debjit Das

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  1. Debjit Das
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Correspondence to Debjit Das.

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Das, D. Ascorbic acid: an efficient organocatalyst for environmentally benign synthesis of indole-substituted 4H‑chromenes. Monatsh Chem 152, 987–991 (2021). https://doi.org/10.1007/s00706-021-02824-5

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  • DOI: https://doi.org/10.1007/s00706-021-02824-5

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