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An eco-compatible, three-component synthesis of acyl-substituted bis(pyrazolyl)methanes by employing recyclable silica sodium carbonate as an efficient and environmentally benign catalyst in aqueous medium

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Abstract

In this work, an efficient and green protocol for the synthesis of newly prepared acyl-substituted bis(pyrazolyl)methane derivatives has been introduced via a one-pot, three-component (2 + 1) condensation reaction by the use of 3-methyl-1-phenyl-2-pyrazolin-5-one, arylglyoxal derivatives, and silica sodium carbonate (SSC) as a recyclable green catalyst. All synthesized products were obtained with good to excellent yields, and their structures were deduced by FT-IR, 1H NMR, 13C NMR spectroscopies, and (C, H, N, S) elemental analyses. The capability of SSC to be reused can be considered as one of this procedure’s advantages. The studies on the reusability of catalyst revealed that SSC can efficiently catalyze this condensation reaction up to six times without significant loss of activity.

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Acknowledgements

The authors would like gratefully to thank the Yasouj University Research Council for their partial support in this work.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

    Khalil Eskandari, Yaghoub Pourshojaei & Ali Asadipour

  2. Department of Chemistry, Faculty of Basic Sciences, Yasouj University, P. O. Box 353, Yasouj, 75918-74831, Iran

    Bahador Karami

Authors
  1. Khalil Eskandari
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  2. Bahador Karami
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  3. Yaghoub Pourshojaei
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  4. Ali Asadipour
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Correspondence to Khalil Eskandari.

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Eskandari, K., Karami, B., Pourshojaei, Y. et al. An eco-compatible, three-component synthesis of acyl-substituted bis(pyrazolyl)methanes by employing recyclable silica sodium carbonate as an efficient and environmentally benign catalyst in aqueous medium. Monatsh Chem 149, 1075–1081 (2018). https://doi.org/10.1007/s00706-017-2106-6

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  • DOI: https://doi.org/10.1007/s00706-017-2106-6

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