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Catalyzed synthesis of functionalized pyrrolo[3,4-b]quinolines via one-pot three-component reactions under conventional and nonconventional conditions

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Abstract

A general, facile, and efficient method for the synthesis of pyrrolo[3,4-b]quinolines is presented. The reactions pathway involve one-pot three-component reactions of β-enamino imides, aromatic aldehydes, and dimedone catalyzed by trifluoroacetic acid, under conventional thermal heating or ultrasounds irradiation, as nonconventional method of synthesis. It is shown that under ultrasounds irradiation, the reaction time decreases significantly (from hours to minutes) and, in some cases, the yields are much better.

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Acknowledgement

This work was financially supported by the Ministry of Education and Science of Ukraine, Scientific Research Project (Project Number: 0116U006958).

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Authors and Affiliations

  1. Yu. Fedkovych Chernivtsi National University, 2 Kotsyubinsky St., Chernivtsi, 58012, Ukraine

    Renata I. Eften’eva, Oleg V. Kushnir & Oleksandr S. Lyavinets

  2. “Al. I. Cuza” University of Iasi, Faculty of Chemistry, Bd. Carol 11, 700506, Iasi, Romania

    Ionel I. Mangalagiu

  3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kiev, 02094, Ukraine

    Myhailo V. Vovk

Authors
  1. Renata I. Eften’eva
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  2. Oleg V. Kushnir
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  3. Oleksandr S. Lyavinets
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  4. Ionel I. Mangalagiu
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  5. Myhailo V. Vovk
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Corresponding author

Correspondence to Oleg V. Kushnir.

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Eften’eva, R.I., Kushnir, O.V., Lyavinets, O.S. et al. Catalyzed synthesis of functionalized pyrrolo[3,4-b]quinolines via one-pot three-component reactions under conventional and nonconventional conditions. Monatsh Chem 148, 1745–1752 (2017). https://doi.org/10.1007/s00706-017-1979-8

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  • DOI: https://doi.org/10.1007/s00706-017-1979-8

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