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Synthesis of new quinoxaline, pyrimidine, and pyrazole furochromone derivatives as cytotoxic agents

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Abstract

A series of novel quinoxaline, pyrimidine, and pyrazole furochromone derivatives were synthesized for the first time. These derivatives were prepared under mild conditions using a stepwise efficient methodology. The developed protocol led to the synthesis of furochromone derivatives in moderate to good yields (60–75%). The structures of the prepared derivatives were identified using several spectroscopic techniques including IR, NMR, and mass spectrometry. The cytotoxic activity of the synthesized derivatives was evaluated using in vitro Ehrlich ascites assay. Pyrazolobenzofurans exhibited the most potent effect suggesting the importance of pyrazole nucleus for the cytotoxic activity.

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Acknowledgement

The authors would like to thank Prof. Dr. Farid Abd-Elraheem Badria (Department of Pharmacognosy, Faculty of Pharmacy and Mansoura University 35516, Egypt) for carrying out the biological activity tests. The presented work was supported by the Department of Photochemistry (Heterocyclic unit); Chemical Industries Research Division, National Research Centre in Cairo, Egypt.

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Authors and Affiliations

  1. Photochemistry Department (Heterocyclic Unit), National Research Center, Dokki, Giza, 12622, Egypt

    Ameen A. Abu-Hashem

  2. Chemistry Department, Faculty of Science, Jazan University, Jezan, 2097, Saudi Arabia

    Ameen A. Abu-Hashem

  3. Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt

    Mohamed El-Shazly

Authors
  1. Ameen A. Abu-Hashem
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  2. Mohamed El-Shazly
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Correspondence to Ameen A. Abu-Hashem.

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Abu-Hashem, A.A., El-Shazly, M. Synthesis of new quinoxaline, pyrimidine, and pyrazole furochromone derivatives as cytotoxic agents. Monatsh Chem 148, 1853–1863 (2017). https://doi.org/10.1007/s00706-017-1960-6

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  • DOI: https://doi.org/10.1007/s00706-017-1960-6

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