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Anti-inflammatory activity of (2E,15E)-2-[1-(2-aminophenyl)ethylidineamino]-N′-[1-(2-aminophenyl)ethylidene]benzoic acid hydrazide (AEBH) and some of its nanoparticles rare earth complexes

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Abstract

Complexes of Er(III), Gd(III), and La(III) with (2E,15E)-2-[1-(2-aminophenyl)ethylidineamino]-N′-[1-(2-aminophenyl)ethylidene]benzoic acid hydrazide (AEBH) have been synthesized. The isolated complexes were characterized by elemental analyses, thermal analyses (TGA, DTA), IR, 1H NMR, 13C NMR, ES-MS, TEM, and conductance measurements. The results indicated that the ligand coordinates to La(III), Gd(III), and Er(III) in the keto form as neutral pentadentate ligand. The particle size and morphology have been determined by TEM. In vivo pharmacological evaluation of the synthesized compounds in collagen II—Freund’s adjuvant model proved the presence of anti-inflammatory and analgesic activities of these compounds. Gd(III) complex showed higher effect in comparison with the well-known drug meloxicam.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Port-Said University, 23 December Street, Port-Said, Egypt

    Nasser Mohammed Hosny

  2. Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Ulla, Kingdom of Saudi Arabia

    Yousery E. Sherif

  3. Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Yousery E. Sherif

Authors
  1. Nasser Mohammed Hosny
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  2. Yousery E. Sherif
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Correspondence to Nasser Mohammed Hosny.

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Hosny, N.M., Sherif, Y.E. Anti-inflammatory activity of (2E,15E)-2-[1-(2-aminophenyl)ethylidineamino]-N′-[1-(2-aminophenyl)ethylidene]benzoic acid hydrazide (AEBH) and some of its nanoparticles rare earth complexes. Monatsh Chem 147, 1893–1902 (2016). https://doi.org/10.1007/s00706-016-1709-7

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  • DOI: https://doi.org/10.1007/s00706-016-1709-7

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