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La(III), Ce(III), Pr(III) and Eu(III) complexes with fenamic acid based ligands: preparation, spectral and thermal analysis and evaluation of their cytotoxicity in MDA-MB-231 breast cancer cells

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Abstract

Six lanthanide complexes with substituted fenamic acid ligands {[La(L1)3].2H2O (C1), [La(L2)3].2H2O (C2), [Ce(L1)3] (C3), [Ce(L2)3].2H2O (C4), [Pr(L1)3].3H2O (C5) and [Eu(L2)3] (C6); HL1 = 2-(4-chlorophenylamino)benzoic acid and HL2 = 2-(4-methoxyphenylamino)benzoic acid} were isolated and characterized by elemental CHN microanalyses, DMF solution electrical conductivities and spectral (FTIR and UV–Visible) data. These analyses assigned the monoanionic character of the ligands and their bidentate chelation mode through the carboxylate group oxygen atoms. In addition, the complexes dissolve in dichloromethane, dimethylformamide and dimethyl sulfoxide, and are nonelectrolytes. Thermo-analytical techniques (TG/DTA) analyzed the complexes in the air and revealed that all water contained in them is lattice-based (uncoordinated), while complexes C3 and C6 are anhydrous. Moreover, all complexes, during heating up to 700 °C, decomposed to the respective oxides (Ln2O3). The complexes were tested for potential activity against human MDA-MB-231 breast cancer cells and the results uncovered low cytotoxic effect with high IC50 doses, comparing to paclitaxel, on these cells.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516, Egypt

    Hanan K. Mosbah, Ahmed B. M Ibrahim, Amna S. A. Zidan & Aref A. M. Aly

  2. Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia

    Ahmed B. M Ibrahim

  3. Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt

    Saber H. Saber

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  1. Hanan K. Mosbah
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All authors contributed equally in this research conceptualization, methodology, investigation, writing-original draft preparation and writing-review and editing. All authors have read and agreed to the published version of the manuscript.

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Mosbah, H.K., Ibrahim, A.B.M., Zidan, A.S.A. et al. La(III), Ce(III), Pr(III) and Eu(III) complexes with fenamic acid based ligands: preparation, spectral and thermal analysis and evaluation of their cytotoxicity in MDA-MB-231 breast cancer cells. J IRAN CHEM SOC 21, 1681–1689 (2024). https://doi.org/10.1007/s13738-024-03033-7

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