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Eco-friendly synthesis of amidochloroalkylnaphthols and its related oxazepinones with biological evaluation

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Abstract

A general mild and efficient protocol for the synthesis of amidochloroalkylnaphthol libraries was achieved utilizing SiO2–ZnCl2 (silzic) as a reusable heterogeneous catalyst via Ritter-type reaction, through one-pot, three-component condensation of various aldehydes, chloroacetonitrile, and β-naphthol under solvent-free reaction conditions. The amidochloroalkylnaphthols were cyclized to its related oxazepinones, and their anticancer and antioxidant activities were studied.

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Acknowledgments

Financial support by National Research Center (Cairo, Egypt) is gratefully appreciated.

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Authors and Affiliations

  1. Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt

    Hanan A. Soliman

  2. Chemistry Department, Faculty of Science, Mansoura University, 35516, Mansoura, Egypt

    Ahmed Y. Mubarak, Ahmed El-Mekabaty & Saad S. Elmorsy

  3. Department of Tanning Materials and Leather Technology, National Research Centre, Dokki, Cairo, Egypt

    Hanem M. Awad

Authors
  1. Hanan A. Soliman
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  2. Ahmed Y. Mubarak
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  3. Ahmed El-Mekabaty
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  4. Hanem M. Awad
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  5. Saad S. Elmorsy
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Correspondence to Hanan A. Soliman.

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Soliman, H.A., Mubarak, A.Y., El-Mekabaty, A. et al. Eco-friendly synthesis of amidochloroalkylnaphthols and its related oxazepinones with biological evaluation. Monatsh Chem 147, 809–816 (2016). https://doi.org/10.1007/s00706-015-1536-2

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  • DOI: https://doi.org/10.1007/s00706-015-1536-2

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