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Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases

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Abstract

The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer chromatography. In order to determine retention parameter as a measure of the lipophilicity of the tested compounds, three different binary solvent systems, composed of water and organic modifier (methanol, acetonitrile, and tetrahydrofuran), were used. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis. Principal component analysis was employed to reveal the most influential factors governing the lipophilicity of the investigated compounds. Finally, the influence of organic modifier on determination of lipophilicity parameters was discussed.

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Acknowledgments

This work was performed within the framework of the research Project No. 172017 supported by the Ministry of Education, Science and Technological development of Serbia.

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Authors and Affiliations

  1. Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia

    Danica S. Perušković, Branka Darić, Nikola R. Stevanović, Aleksandra V. Pavlović, Aleksandar Đ. Lolić & Rada M. Baošić

  2. Department of Chemistry, J. J. Strossmayer University, Franje Kuhaca 20, Osijek, Croatia

    Anita Blagus

Authors
  1. Danica S. Perušković
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  2. Branka Darić
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  3. Anita Blagus
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  4. Nikola R. Stevanović
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  5. Aleksandra V. Pavlović
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  6. Aleksandar Đ. Lolić
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  7. Rada M. Baošić
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Correspondence to Rada M. Baošić.

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Perušković, D.S., Darić, B., Blagus, A. et al. Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases. Monatsh Chem 146, 1–6 (2015). https://doi.org/10.1007/s00706-014-1313-7

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  • DOI: https://doi.org/10.1007/s00706-014-1313-7

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