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Isocyanide-based one-pot three-component synthesis of novel spiroiminolactone derivatives in water

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Abstract

A new and efficient isocyanide-based one-pot multi-component approach for the synthesis of novel spiroiminolactone derivatives is described. Products were obtained by a three-component condensation reaction of 1,3-diones, reactive cyclic carbonyl compounds, and isocyanides in the presence of a catalytic amount of tetrabutylammonium hydrogensulfate in water. Using this method, target compounds were synthesized with great efficiency and atom economy.

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Acknowledgments

We are grateful to the Islamic Azad University (Shiraz Branch) Research Councils for the financial support of this work. We also thank Dr. M. M. Ghanbari, faculty member of the Islamic Azad University (Sarvestan Branch), for his useful advice.

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Authors and Affiliations

  1. Department of Applied Chemistry, Shiraz Branch, Islamic Azad University, P.O. Box 71993-5, Shiraz, Iran

    Hamid Reza Safaei & Najva Shioukhi

  2. Department of Chemistry, College of Sciences, Shiraz University, 71454, Shiraz, Iran

    Mohsen Shekouhy

Authors
  1. Hamid Reza Safaei
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  2. Najva Shioukhi
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  3. Mohsen Shekouhy
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Correspondence to Hamid Reza Safaei.

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Safaei, H.R., Shioukhi, N. & Shekouhy, M. Isocyanide-based one-pot three-component synthesis of novel spiroiminolactone derivatives in water. Monatsh Chem 144, 1855–1863 (2013). https://doi.org/10.1007/s00706-013-1060-1

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  • DOI: https://doi.org/10.1007/s00706-013-1060-1

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