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Synthesis, anticancer, and antimicrobial activities of some new antipyrine-based heterocycles

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Abstract

A facile and convenient synthesis of [1,2,3]triazole, [1,2,4]triazolo[5,1-c][1,2,4]triazine, and pyrazolo[5,1-c][1,2,4]triazine derivatives incorporating an antipyrin-4-yl or antipyrin-4-ylcarboxamide moiety via the versatile, readily accessible 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide is described. Structures of the synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and mass spectral data. The biological activity of the newly synthesized compounds was examined and some of them were found to possess anticancer and antimicrobial activities.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt

    Sayed M. Riyadh & Nabila A. Kheder

  2. Department of Chemistry, Faculty of Science, King Khalid University, Abha, 9004, Kingdom of Saudi Arabia

    Sayed M. Riyadh & Ahlam M. Asiry

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha, 61441, Kingdom of Saudi Arabia

    Nabila A. Kheder

Authors
  1. Sayed M. Riyadh
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  2. Nabila A. Kheder
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  3. Ahlam M. Asiry
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Correspondence to Nabila A. Kheder.

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Riyadh, S.M., Kheder, N.A. & Asiry, A.M. Synthesis, anticancer, and antimicrobial activities of some new antipyrine-based heterocycles. Monatsh Chem 144, 1559–1567 (2013). https://doi.org/10.1007/s00706-013-1028-1

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  • DOI: https://doi.org/10.1007/s00706-013-1028-1

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