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Joint occurrence of the bubble protein and mycophenolic acid in Penicillium brevicompactum Dierckx

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Abstract

Colonies of the fungus Penicillium brevicompactum Dierckx contain exudate droplets on the surface of the mycelia when grown on Murashige and Skoog medium. It was previously shown that the exudate is enriched in the bubble protein. Here, we show that the exudate bubbles are also enriched in a fluorescent non-protein molecule, which upon isolation and characterisation was determined as mycophenolic acid. Based on this discovery, mycophenolic acid from exudate bubbles may constitute an alternative source for purification of the metabolite for clinical use.

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Authors and Affiliations

  1. University of Vienna, Institute of Theoretical Chemistry, Währinger Strasse 17, 1090, Vienna, Austria

    Marcus Seibold & Peter Wolschann

  2. Carlsberg Group Research, Gamle Carlsberg Vej 10, 1799, Copenhagen, Denmark

    Ole Olsen

Authors
  1. Marcus Seibold
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  2. Peter Wolschann
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  3. Ole Olsen
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Correspondence to Marcus Seibold.

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Seibold, M., Wolschann, P. & Olsen, O. Joint occurrence of the bubble protein and mycophenolic acid in Penicillium brevicompactum Dierckx . Monatsh Chem 142, 1309–1315 (2011). https://doi.org/10.1007/s00706-011-0668-2

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  • DOI: https://doi.org/10.1007/s00706-011-0668-2

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