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A ring-closing metathesis approach for the synthesis of (±)-pregabalin

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Abstract

Efficient utilization of a Mannich-type reaction and the ring-closing metathesis (RCM) approach that leads to a convenient synthesis of 3-(aminomethyl)-5-methylhexanoic acid (pregabalin) is described.

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Acknowledgments

This work was supported by the University Grants Commission, New Delhi. We thank Prof. D.D. Dhavale, University of Pune, for useful discussions and help.

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Authors and Affiliations

  1. Postgraduate Department of Chemistry, H. P. T. Arts and R. Y. K. Science College, Nashik, 422 005, India

    Vivek D. Bobade, Pravin C. Mhaske, Kamlesh S. Vadgaonkar & Shivaji H. Shelke

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  1. Vivek D. Bobade
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  2. Pravin C. Mhaske
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  3. Kamlesh S. Vadgaonkar
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  4. Shivaji H. Shelke
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Correspondence to Vivek D. Bobade.

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Bobade, V.D., Mhaske, P.C., Vadgaonkar, K.S. et al. A ring-closing metathesis approach for the synthesis of (±)-pregabalin. Monatsh Chem 143, 847–851 (2012). https://doi.org/10.1007/s00706-011-0654-8

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  • DOI: https://doi.org/10.1007/s00706-011-0654-8

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